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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 424 - 430 (7page)
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초록· 키워드
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Autophagy, an evolutionarily conserved cellular degradation pathway of the lysosome, is associated with many physiological and pathological processes. The hallmark of autophagy is the formation of the autophagosome that engulfs and degrades cytosolic components via its fusion with the lysosome, in either a selective or a non-selective manner.
Autophagy is tightly regulated by proteins encoded by autophagy-related (atg) genes. Among these proteins, ATG8/ LC3 is essential for autophagosome biogenesis/maturation and it also functions as an adaptor protein for selective autophagy.
In mammalian cells, several homologs of yeast Atg8 such as MAP1LC3, GABARAP, and GABARAPL 1/2 have been identified. However, the biological relevance of this gene diversity in higher eukaryotes, and their specific roles, are largely unknown. In this review, we describe the mammalian ATG8/LC3 family and discuss recent advancements in understanding their roles in the autophagic process.
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참고문헌 (44)
참고문헌 신청
Klionsky DJ / 2013 / The mechanism and physiological function of macroautophagy / J Innate Immun 5:427~433
Klionsky DJ / 2007 / Autophagy : from phenomenology to molecular understanding in less than a decade / Nat Rev Mol Cell Biol 8:931~937
Schneider JL / 2014 / Autophagy and human disease: emerging themes / Curr Opin Genet Dev 26:16~23
Ktistakis NT / 2016 / Digesting the Expanding Mechanisms of Autophagy / Trends Cell Biol 26:624~635
Ponpuak M / 2015 / Secretory autophagy / Curr Opin Cell Biol 35:106~116
Klionsky DJ / 2007 / Autophagy : from phenomenology to molecular understanding in less than a decade / Nat Rev Mol Cell Biol 8:931~937
Schneider JL / 2014 / Autophagy and human disease: emerging themes / Curr Opin Genet Dev 26:16~23
Ktistakis NT / 2016 / Digesting the Expanding Mechanisms of Autophagy / Trends Cell Biol 26:624~635
Ponpuak M / 2015 / Secretory autophagy / Curr Opin Cell Biol 35:106~116
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