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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 345 - 354 (10page)
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초록· 키워드
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Autophagy, a catabolic process necessary for the maintenance of intracellular homeostasis, has recently been the focus of numerous human diseases and conditions, such as aging, cancer, development, immunity, longevity, and neurodegeneration.
However, the continued presence of autophagy is essential for cell survival and dysfunctional autophagy is thought to speed up the progression of neurodegeneration.
The actual molecular mechanism behind the progression of dysfunctional autophagy is not yet fully understood. Emerging evidence suggests that basal autophagy is necessary for the removal of misfolded, aggregated proteins and damaged cellular organelles through lysosomal mediated degradation.
Physiologically, neurodegenerative disorders are related to the accumulation of amyloid ? peptide and ?-synuclein protein aggregation, as seen in patients with Alzheimer’s disease and Parkinson’s disease, respectively. Even though autophagy could impact several facets of human biology and disease, it generally functions as a clearance for toxic proteins in the brain, which contributes novel insight into the pathophysiological understanding of neurodegenerative disorders. In particular, several studies demonstrate that natural compounds or small molecule autophagy enhancer stimuli are essential in the clearance of amyloid ? and ?-synuclein deposits. Therefore, this review briefly deliberates on the recent implications of autophagy in neurodegenerative disorder control, and emphasizes the opportunities and potential therapeutic application of applied autophagy.
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참고문헌 (104)
참고문헌 신청
Mizushima N / 2008 / Autophagy fights disease through cellular selfdigestion / Nature 451:1069~1075
Kotoulas OB / 2006 / Glycogen autophagy in glucose homeostasis / Pathol Res Pract 202:631~638
Singh R / 2009 / Autophagy regulates lipid metabolism / Nature 458:1131~1135
Rubinsztein DC / 2011 / Autophagy and aging / Cell 146:682~695
Toth ML / 2008 / Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans / Autophagy 4:330~338
Kotoulas OB / 2006 / Glycogen autophagy in glucose homeostasis / Pathol Res Pract 202:631~638
Singh R / 2009 / Autophagy regulates lipid metabolism / Nature 458:1131~1135
Rubinsztein DC / 2011 / Autophagy and aging / Cell 146:682~695
Toth ML / 2008 / Longevity pathways converge on autophagy genes to regulate life span in Caenorhabditis elegans / Autophagy 4:330~338
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