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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 254 - 259 (6page)
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Increasing evidence suggests the role of miR-449a in the regulation of tumorigenesis and autophagy. Autophagy plays an important role in the malignancy of T-cell lymphoma. However, it is still unknown whether miR-449a is associated with autophagy to regulate the malignancy of T-cell lymp homa. In this study, we for the first time demonstrated that miR-449a enhanced apoptosis of T-cell lymphoma cells by decreasing the degree of autophagy. Further, miR-449a downregulated autophagy- associated 4B (ATG4B) expression, which subsequently reduced the autophagy of T-cell lymphoma cells. Mechanistically, miR-449a decreased ATG4B protein level by binding to its mRNA 3’UTR, thus reducing the mRNA stability. In addition, studies with nude mice showed that miR-449a significantly inhibited lymphoma characteristics in vivo. In conclusion, our results demonstrated that the “miR-449a/ATG4B/autophagy” pathway played a vital role in the malignancy of T-cell lymphoma, suggesting a novel therapeutic target.
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참고문헌 (32)
참고문헌 신청
Sermer D / 2019 / Emerging epigenetic-modulating therapies in lymphoma / Nat Rev Clin Oncol 16:494~507
Shi Y / 2015 / Results from a multicenter, open-label, pivotal phase II study of chidamide in relapsed or refractory peripheral T-cell lymphoma / Ann Oncol 26:1766~1771
Ji MM / 2018 / Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified / Haematologica 103:679~687
Van Arnam JS / 2018 / Novel insights into the pathogenesis of T-cell lymphomas / Blood 131:2320~2330
Pfister AS / 2019 / Emerging Role of the Nucleolar Stress Response in Autophagy / Front Cell Neurosci 13:156
Shi Y / 2015 / Results from a multicenter, open-label, pivotal phase II study of chidamide in relapsed or refractory peripheral T-cell lymphoma / Ann Oncol 26:1766~1771
Ji MM / 2018 / Histone modifier gene mutations in peripheral T-cell lymphoma not otherwise specified / Haematologica 103:679~687
Van Arnam JS / 2018 / Novel insights into the pathogenesis of T-cell lymphomas / Blood 131:2320~2330
Pfister AS / 2019 / Emerging Role of the Nucleolar Stress Response in Autophagy / Front Cell Neurosci 13:156
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