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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 75 - 81 (7page)
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Cytomegalovirus (CMV) is a clinically important pathogen in immunocompromised patients, especially after organ transplantation. However, there have been several reports of severe CMV infections in immunocompetent patients. This report presents a case of an immunocompetent patient who presented with fulminant hepatitis requiring liver transplantation. Because CMV was detected upon histopathologic review of the explanted liver, it was later assumed that CMV may be the primary cause of hepatitis. However, at the time of transplantation, we did not suspect CMV hepatitis. Following transplantation and initiation of immunosuppression, the patient developed viral sepsis with a disseminated CMV infection. Respiratory failure because of CMV pneumonia worsened despite antiviral therapy, and venovenous extracorporeal membrane oxygenation (ECMO) was initiated. Although ECMO has been traditionally contraindicated in patients with sepsis, this patient recovered and was successfully weaned off ECMO. CMV should be included in the differential diagnosis of fulminant hepatitis, even in immunocompetent patients, especially when liver transplantation is considered.
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참고문헌 (20)
참고문헌 신청
Nguyen Q / 2001 / Cytomegalovirus pneumonia in adults with leukemia : an emerging problem / Clin Infect Dis 32:539~545
Rafailidis PI / 2008 / Severe cytomegalovirus infection in apparently immunocompetent patients : a systematic review / Virol J 5:47
Wreghitt TG / 2003 / Cytomegalovirus infection in immunocompetent patients / Clin Infect Dis 37:1603~1606
Brodie D / 2011 / Extracorporeal membrane oxygenation for ARDS in adults / N Engl J Med 365:1905~1914
Karagiannidis C / 2016 / Extracorporeal membrane oxygenation : evolving epidemiology and mortality / Intensive Care Med 42:889~896
Rafailidis PI / 2008 / Severe cytomegalovirus infection in apparently immunocompetent patients : a systematic review / Virol J 5:47
Wreghitt TG / 2003 / Cytomegalovirus infection in immunocompetent patients / Clin Infect Dis 37:1603~1606
Brodie D / 2011 / Extracorporeal membrane oxygenation for ARDS in adults / N Engl J Med 365:1905~1914
Karagiannidis C / 2016 / Extracorporeal membrane oxygenation : evolving epidemiology and mortality / Intensive Care Med 42:889~896
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