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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 217 - 222 (6page)
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Phagocytosis is a fundamental process in which phagocytes capture and ingest foreign particles including pathogenic bacteria. Several oral pathogens have anti-phagocytic strategies, which allow them to escape from and survive in phagocytes. Impaired bacteria phagocytosis increases inflammation and contributes to inflammatory diseases. The purpose of this study is to investigate the influences of various agents on oral pathogenic phagocytosis. To determine phagocytosis, Streptococcus mutans, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis were stained with 5-(and-6)-carboxyfluorescein diacetate succinimidyl ester (CFSE), and was measured using flowcytometery and confocal microscopy. The influencing factors on phagocytosis were evaluated through the pretreatment of ROS inhibitor (N-acetyl-L-cysteine (NAC)), lysozyme, potassium chloride (KCI) and adenosine triphosphate (ATP) in THP-1 cells. Expression of pro-inflammatory cytokines was determined by enzyme-linked immunosorbent assay (ELISA). The phagocytosis of various bacteria increased in a MOI-dependent manner. Among the tested bacteria, phagocytosis of P. gingivalis showed the highest fluorescent intensity at same infection time. Among the tested inhibitors, the NAC treatment significantly inhibited phagocytosis in all tested bacteria. In addition, NAC treatment indicated a similar pattern under the confocal microscopy. Moreover, NAC treatment significantly increased the bacteria- induced secretion of IL-1β among the tested inhibitors. Taken together, we conclude that the phagocytosis occurs differently depending on each bacterium. Down-regulation by ROS production inhibited phagocytosis and lead increased of oral pathogens-associated inflammation.
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참고문헌 (26)
참고문헌 신청
Lim JJ / 2017 / Diversity and versatility of phagocytosis: roles in innate immunity, tissue remodeling, and homeostasis / Front Cell Infect Microbiol 7:191
Rosales C / 2017 / Phagocytosis: a fundamental process in immunity / Biomed Res Int 2017:9042851
Rabinovitch M / 1995 / Professional and non-professional phagocytes:an introduction / Trends Cell Biol 5:85~87
SiamonGordon / 2016 / Phagocytosis: An Immunobiologic Process / Immunity 44(3):463~475
Shklair IL / 1969 / A study of some factors influencing phagocytosis of cariogenic streptococci by caries-free and caries-active individuals / J Dent Res 48(5):842~845
Rosales C / 2017 / Phagocytosis: a fundamental process in immunity / Biomed Res Int 2017:9042851
Rabinovitch M / 1995 / Professional and non-professional phagocytes:an introduction / Trends Cell Biol 5:85~87
SiamonGordon / 2016 / Phagocytosis: An Immunobiologic Process / Immunity 44(3):463~475
Shklair IL / 1969 / A study of some factors influencing phagocytosis of cariogenic streptococci by caries-free and caries-active individuals / J Dent Res 48(5):842~845
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