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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 84 - 90 (7page)
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Background and Purpose Neonatal hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of neurological handicap in developing countries. Human umbilical cord blood (hUCB) CD34-positive (CD34+) stem cells exhibit the potential for neural repair. We tested the hypothesis that hUCB CD34+ stem cells and other cell types [leukocytes and nucleated red blood cells (NRBCs)] that are up-regulated during the acute stage of perinatal asphyxia (PA) could play a role in the early prediction of the occurrence, severity, and mortality of HIE.
Methods This case-control pilot study investigated consecutive neonates exposed to PA. The hUCB CD34+ cell count in mononuclear layers was assayed using a flow cytometer. Twenty full-term neonates with PA and 25 healthy neonates were enrolled in the study.
Results The absolute CD34+ cell count (p=0.02) and the relative CD34+ cell count (CD34+%) (p<0.001) in hUCB were higher in the HIE patients (n=20) than the healthy controls. The hUCB absolute CD34+ cell count (p=0.04), CD34+% (p<0.01), and Hobel risk scores (p=0.04) were higher in patients with moderate-to-severe HIE (n=9) than in those with mild HIE (n=11). The absolute CD34+ cell count was strongly correlated with CD34+% (p<0.001), Hobel risk score (p=0.04), total leukocyte count (TLC) (p<0.001), and NRBC count (p=0.01). CD34+% was correlated with TLC (p=0.02).
Conclusions hUCB CD34+ cells can be used to predict the occurrence, severity, and mortality of neonatal HIE after PA.
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참고문헌 (24)
참고문헌 신청
Aly H / 2009 / Vascular endothelial growth factor in neonates with perinatal asphyxia / Brain Dev 31 : 600 ~ 604
Axt R / 1999 / Nucleated red blood cells in cord blood of singleton term and post-term neonates / J Perinat Med 27 : 376 ~ 381
Bhongir AV / 2015 / The urinary uric acid/creatinine ratio is an adjuvant marker for perinatal asphyxia / Eur J Pharm Med Res 2 : 520 ~ 528
Chalak LF / 2014 / Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III / J Perinatol 34 : 629 ~ 633
Denning-Kendall PA / 1999 / Different behaviour of fresh and cultured CD34+ cells during immunomagnetic separation / Br J Haematol 105 : 780 ~ 785
Axt R / 1999 / Nucleated red blood cells in cord blood of singleton term and post-term neonates / J Perinat Med 27 : 376 ~ 381
Bhongir AV / 2015 / The urinary uric acid/creatinine ratio is an adjuvant marker for perinatal asphyxia / Eur J Pharm Med Res 2 : 520 ~ 528
Chalak LF / 2014 / Neurodevelopmental outcomes after hypothermia therapy in the era of Bayley-III / J Perinatol 34 : 629 ~ 633
Denning-Kendall PA / 1999 / Different behaviour of fresh and cultured CD34+ cells during immunomagnetic separation / Br J Haematol 105 : 780 ~ 785
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