지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 39 - 43 (5page)
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초록· 키워드
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Objective: Weight gain is a possible adverse effect of the use of antipsychotics, and is an important factor for long-term health and treatment compliance. Olanzapine is an atypical antipsychotic known to cause considerable weight gain. A relationship between weight gain and the G protein β3 subunit gene (GNB3) 825C/T polymorphism has been reported. We
therefore examined this possible association in a Korean schizophrenic patient group receiving olanzapine treatment.
Methods: Weight and height measurements were obtained prior to starting olanzapine and measured again after long-term treatment. Genotyping for the 825C/T polymorphism was performed using a PCR-based method.
Results: We found that long-term treatment with olanzapine resulted in mean gains in weight and body mass index (BMI) of 5.2 ㎏ and 1.93 ㎏/㎡, respectively. There was a no significant difference in the mean body weight change from baseline to the endpoint after olanzapine treatment between the genotype groups (p=0.796). There were also no significant differences in genotype or allele frequencies between the severe weight-gain (more than 10%) and minimal weight-gain (less than 10%) groups (χ2=0.037, p=0.98; χ2=0.020, p=0.89).
Conclusion: The finding from this study thus does not support a relationship between the GNB3 825C/T polymorphism and weight gain in Korean schizophrenic patients receiving olanzapine treatment.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Allison DB / 1999 / Antipsychotic-induced weight gain: a comprehensive research synthesis / Am J Psychiatry 156 : 1686 ~ 1696
Allison DB / 2003 / The impact of weight gain on quality of life among persons with schizophrenia / Psychiatr Serv 54 : 565 ~ 567
Benjafield AV / 2001 / G-protein beta3 subunit gene splice variant in obesity and overweight / Int J Obes Relat Metab Disord 25 : 777 ~ 780
Bishop JR / 2006 / Pilot study of the Gprotein beta3 subunit gene (C825T) polymorphism and clinical response to olanzapine or olanzapine-related weight gain in persons with
Casey DE / 2001 / The pharmacology of weight gain with antipsychotics / J Clin Psychiatry 62 (7) : 4 ~ 10
Allison DB / 2003 / The impact of weight gain on quality of life among persons with schizophrenia / Psychiatr Serv 54 : 565 ~ 567
Benjafield AV / 2001 / G-protein beta3 subunit gene splice variant in obesity and overweight / Int J Obes Relat Metab Disord 25 : 777 ~ 780
Bishop JR / 2006 / Pilot study of the Gprotein beta3 subunit gene (C825T) polymorphism and clinical response to olanzapine or olanzapine-related weight gain in persons with
Casey DE / 2001 / The pharmacology of weight gain with antipsychotics / J Clin Psychiatry 62 (7) : 4 ~ 10
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