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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한신경정신의학회 PSYCHIATRY INVESTIGATION PSYCHIATRY INVESTIGATION 제7권 제1호
발행연도
2010.1
수록면
55 - 59 (5page)

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Objective: Antidepressants used to treat depression are frequently associated with sexual dysfunction. Sexual side effects affect the patient’s quality of life and, in long-term treatment, can lead to non-compliance and relapse. However, studies covering many antidepressants with differing mechanisms of action were scarce. The present study assessed and compared the incidence of sexual dysfunction among different antidepressants in a naturalistic setting. Methods: Participants were married patients diagnosed with depression, per DSM-IV diagnostic criteria, who had been taking antidepressants for more than 1 month. We assessed the participants via the Arizona Sexual Experiences Scale (ASEX), Beck Depression Inventory (BDI), and State-Trait Anxiety Inventory (STAI), and assessed their demographic variables, types and dosages of antidepressants, and duration of antidepressant use via their medical records. Results: One hundred and one patients (46 male, 55 female, age 42.2±7 years) completed the instruments. Thirteen were taking fluoxetine (mean dose 21.3±8.5 mg/day), 24 were taking paroxetine (mean dose 20.4±7.2 mg/day), 20 taking citalopram (mean dose 22.1±6.5 mg/day), 22, venlafaxine (mean dose 115.7±53.2 mg/day) and 22, mirtazapine (mean dose 18±8.7 mg/day). Mean ages, sex ratios, and BDI and STAI scores did not differ significantly across antidepressants. A substantial number of participants (46.5%, n=47) experienced sexual dysfunction. The prevalence of sexual dysfunction differed across drugs: citalopram 60% (n=12), venlafaxine 54.5% (n=12), paroxetine 54.2% (n=13), fluoxetine 46.2% (n=6), and mirtazapine 18.2% (n=4). Regression analyses revealed the significant factors for sexual dysfunction were being female, total scores on the BDI and SAI, and type of antidepressant (F=4.92, p<0.0001). Of the antidepressants, the mirtarzapine group’s total ASEX score was significantly lower than the scores of the citalopram, fluoxetine, and paroxetine groups. Conclusion: The incidence of sexual dysfunction was substantially high during antidepressant treatment. The incidence of sexual dysfunction differed among antidepressants having different mechanisms of action. Our study suggests the need for clinicians to consider the impact of pharmacotherapy on patients’ sexual functioning in the course of treatment with antidepressants.
#Depression #Sexual dysfunction #Antidepressants.

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참고문헌 (24)

참고문헌 신청
Angulo J / 2001 / Differential effects of serotonin reuptake inhibitors on erectile responses, NO-production, and neuronal NO synthase expression in rat corpus cavernosum ti google schola Association AP / 2000 / Diagnostic and statistical manual of mental disorders, 4th edition, text revision / American Psychiatric Association google schola Baldwin DS / 2004 / Sexual dysfunction associated with antidepressant drugs / Expert Opin Drug Saf 3 : 457 ~ 470 google schola Beck AT / 1961 / An inventory for measuring depression / Arch Gen Psychiatry 4 : 561 ~ 571 google schola Boolell M / 1996 / Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction / Int J Impot Res 8 : google schola

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