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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제6권 제1호
- 발행연도
- 2008.1
- 수록면
- 19 - 23 (5page)
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Objective：Despite the availability of various antidepressants, clinicians managing depressed patients still face two challenges: 40-50% of patients will not respond sufficiently to acute treatment, and 2-6 weeks are required before a medication trial can be ruled a failure. Genetic factors contribute to the phenotype of drug response. The pharmacogenomic prediction of the antidepressant response is one possibility for improving the efficiency of antidepressant treatment.
Methods：Monoamine transporters are the site of action of the most commonly used antidepressants. We established a depressive patient cohort and conducted a series of studies of the association between genetic polymorphisms in monoamine transporters and the antidepressant response.
Results：We found specific associations between monoamine transporter polymorphisms and antidepressant responses, an ethnic difference in the association between 5-HTTLPR and selective serotonin reuptake inhibitors, and the predictive potential of combinations of polymorphisms.
Conclusion：We have conducted pharmacogenomic studies of the antidepressant response for 12 years with the goal of increasing the treatment response to antidepressants for each individual depressed patient. This review summarizes our findings.
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참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)
Bellivier F / 1998 / Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression / Neurosci Lett 255 : 143 ~ 146
Durham LK / 2004 / The serotonin transporter polymorphism, 5HTTLPR, is associated with a faster response time to sertraline in an elderly population with major depressive di
Fredman SJ / 2000 / Partial response, nonresponse, and relapse with selective serotonin reuptake inhibitors in major depression; a survey of current “next-step” practice /
Gelernter J / 1997 / Serotonin transporter protein (SCL6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populat
Bellivier F / 1998 / Serotonin transporter gene polymorphisms in patients with unipolar or bipolar depression / Neurosci Lett 255 : 143 ~ 146
Durham LK / 2004 / The serotonin transporter polymorphism, 5HTTLPR, is associated with a faster response time to sertraline in an elderly population with major depressive di
Fredman SJ / 2000 / Partial response, nonresponse, and relapse with selective serotonin reuptake inhibitors in major depression; a survey of current “next-step” practice /
Gelernter J / 1997 / Serotonin transporter protein (SCL6A4) allele and haplotype frequencies and linkage disequilibria in African- and European-American and Japanese populat
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