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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 264 - 269 (6page)
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초록· 키워드
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ObjectiveaaAssociations of thyroid dysfunction with cognitive impairment and depression in late-life have been described but remain controversial. This study aimed to investigate the associations of serum thyroid stimulating hormone (TSH) levels with cognitive impairment and depression after controlling for potential confounding factors.
MethodsaaThe sample consisted of 495 community residents aged 65 or over in whom serum TSH had been assayed. Cognitive impairment was defined using the Community Screening Interview for Dementia, and depression was diagnosed using the Geriatric Mental State schedule. Age, gender, education, smoking history, physical activity, blood pressure, diabetes, and serum total cholesterol and albumin were included as covariates.
ResultsaaThere was a significant association between lower (hyperthyroid) serum TSH levels (<0.5 mIU/L) and cognitive impairment after adjustment [odds ratio 7.12 (95% confidence interval 1.35-37.5)]. However, no association was found between TSH levels and depression.
ConclusionaaBased on TSH levels, hyperthyroidism but not hypothyroidism was associated with cognitive impairment in this sample, and we found no evidence for an association of either with depression.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Biondi B / 2008 / The clinical significance of subclinical thyroid dysfunction / Endocr Rev 29 : 76 ~ 131
Canaris GJ / 2000 / The Colorado thyroid disease prevalence study / Arch Intern Med 160 : 526 ~ 534
Ceresini G / 2009 / Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study / J Am Geriatr Soc 57 : 89 ~ 93
Chueire VB / 2007 / Subclinical hypothyroidism increases the risk for depression in the elderly / Arch Gerontol Geriatr 44 : 21 ~ 28
Copeland JR / 1986 / A computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT / Psychol Med 16 : 89 ~ 99
Canaris GJ / 2000 / The Colorado thyroid disease prevalence study / Arch Intern Med 160 : 526 ~ 534
Ceresini G / 2009 / Thyroid function abnormalities and cognitive impairment in elderly people: results of the Invecchiare in Chianti study / J Am Geriatr Soc 57 : 89 ~ 93
Chueire VB / 2007 / Subclinical hypothyroidism increases the risk for depression in the elderly / Arch Gerontol Geriatr 44 : 21 ~ 28
Copeland JR / 1986 / A computerized psychiatric diagnostic system and case nomenclature for elderly subjects: GMS and AGECAT / Psychol Med 16 : 89 ~ 99
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