지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 189 - 197 (9page)
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초록· 키워드
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Tumor angiogenesis has been related to the initiation as well as progression toward more aggressive behavior of human tumors. In particular, the activity of angiogenic factors is crucial for tumor progression. We previously characterized a secreted fibroblast growth factor-binding protein (FGF-BP) as a chaperone molecule, which binds to various FGFs, enhances FGF-mediated biochemical and biologic events and importantly is a crucial rate-limiting factor for tumor-dependent angiogenesis. We generated monoclonal antibodies that target FGF-BP protein and used them as a tool to evaluate frequency and pattern of FGF-BP expression during the malignant progression of pancreas and colorectal carcinoma in archival tissue samples. We found that FGF-BP is dramatically upregulated during the initiation of colorectal and pancreatic adenocarcinoma. Crucial genetic events underlying the initiation and progression of colorectal and pancreatic adenocarcinoma with a particular focus on the modulation of angiogenesis and antiangiogenic therapies are discussed. We propose that the upregulation of the secreted FGF-BP protein during early phases of pancreas and colon cancer could make this protein a possible serum marker indicating the presence of high-risk premalignant lesions. Furthermore, the biological activity of FGF-BP is neutralized by monoclonal antibodies suggesting the potential for antibody-based therapeutic targeting. (Cancer Res Treat. 2006;38:189-197)
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등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
/ 1972 / new concept for therapy of solid tumors : 409 ~ 16
/ 1990 / What is the evidence that tumors are angiogenesis dependent : 4 ~ 6
/ 1991 / Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors 266 : 16778 ~ 85
/ 1992 / Angiogenesis 267 : 10931 ~ 4
/ 1994 / Tumor growth and angiogenesis induced by a secreted binding protein for fibroblast growth factors 269 : 28243 ~ 8
/ 1990 / What is the evidence that tumors are angiogenesis dependent : 4 ~ 6
/ 1991 / Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors 266 : 16778 ~ 85
/ 1992 / Angiogenesis 267 : 10931 ~ 4
/ 1994 / Tumor growth and angiogenesis induced by a secreted binding protein for fibroblast growth factors 269 : 28243 ~ 8
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