지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 218 - 223 (6page)
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초록· 키워드
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Purpose: The aim of this study was to investigate the prognostic significance of the expression of p53 gene product in operable invasive breast cancer by performing immunohistochemical analysis.
Materials and Methods: Between January 1993 and December 2001, 440 operable invasive breast cancer patients underwent immunohistochemical staining for p53, and we retrospectively analyzed these results together with the clinical outcomes.
Results: The overexpression of p53 was detected in 51.6% of the cases. The overexpression of p53 was inversely correlated with lymph node metastasis (p=0.005). The tumor size, tumor histology, histologic grade, hormonal receptor status and tumor stage were not related to the overexpression of p53. Multivariate Cox regression analysis indicate that lymph node metastasis, tumor size and the p53 expression were the significant prognostic factors for overall survival; lymph node metastasis, the estrogen receptor status and the p53 expression were the significant prognostic factors for relapse free survival. On the subgroup analysis, the p53 non-expressors showed better 7-year overall survival (92.7% vs. 76.7%, respectively, p=0.011) and relapse free survival (74.9% vs. 57.8%, respectively, p=0.032) than did the p53 overexpressors for the patients with lymph node metastasis. However, for the patients without lymph node metastasis, the survival rates were not different for both the p53 non-expressors and the p53 overexpressors.
Conclusion: Immunohistochemical staining of the p53 gene product was an independent prognostic factor for predicting survival of the lymph node positive invasive breast cancer patients. (Cancer Res Treat. 2006;38:218- 223)
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참고문헌 (22)
참고문헌 신청
/ / Association of overexpression of tumor suppressor protein p53 with rapid cell proliferation and poor prognosis in node-negative breast cancer patients1992 : 1109 ~ 14
/ / Immunohistochemistry expression of mutant form of p53 oncogene in primary lung cancer. Lancet. 1990 prog (sis) : 675 ~ 9
/ / Levine AJ. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol. 1988 : 531 ~ 9
/ / Levine AJ. The p53 proto-oncogene can act as a suppressor of transformation. Cell. 1989 : 1083 ~ 93
/ / Milles RR. Immunohistochemical detection of p53 protein in mammary carcinoma an important new independent indicator of prognosis? Hum Pathol. 1993 : 469 ~ 76
/ / Immunohistochemistry expression of mutant form of p53 oncogene in primary lung cancer. Lancet. 1990 prog (sis) : 675 ~ 9
/ / Levine AJ. Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol. 1988 : 531 ~ 9
/ / Levine AJ. The p53 proto-oncogene can act as a suppressor of transformation. Cell. 1989 : 1083 ~ 93
/ / Milles RR. Immunohistochemical detection of p53 protein in mammary carcinoma an important new independent indicator of prognosis? Hum Pathol. 1993 : 469 ~ 76
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