지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 195 - 208 (14page)
- DOI
- https://doi.org/10.3904/kjm.2021.96.3.195
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초록· 키워드
오류제보하기
Chronic lymphocytic leukemia (CLL), characterized by monoclonal B-cell accumulation and highly variable clinical manifestations that range from an indolent to an aggressive course, is rare in Korea. Asymptomatic patients with early stage CLL can be followed up without treatment; however, those with active or advanced disease require treatment immediately after diagnosis, for symptom alleviation and prolonging survival. Previously, chemotherapy using cytotoxic agents was the only therapeutic option available for patients with CLL. Research has provided a deeper understanding of the pathophysiology of the disease, and novel agents such as monoclonal antibodies and small-molecule inhibitors that target specific sites on leukemic cells have been introduced. The advent of these new drugs has led to improved clinical outcomes in patients with CLL. Currently, Bruton’s tyrosine kinase inhibitors or B-cell lymphoma-2 inhibitors are recommended as frontline therapy, prior to the administration of cytotoxic agents or combination therapy with monoclonal antibodies. In this article, we review the diagnosis and prognosis of CLL, in addition to the clinical implications of the various therapeutic options.
목차
등록된 정보가 없습니다.
참고문헌 (79)
참고문헌 신청
Eichhorst B / 2008 / ESMO Guidelines Working Group. Chronic lymphocytic leukemia: ESMO clinical recommendations for diagnosis, treatment and follow-up / Ann Oncol. 19(Suppl 2):ii60~ii62
Dores GM / 2007 / Chronic lymphocytic leukaemia and small lymphocytic lymphoma : overview of the descriptive epidemiology / Br J Haematol 139:809~819
이혜원 / 2018 / Nationwide Statistical Analysis of Lymphoid Malignancies in Korea / Cancer Research and Treatment 50(1):222~238
Gunawardana C / 2008 / South Asian chronic lymphocytic leukaemia patients have more rapid disease progression in comparison to White patients / Br J Haematol 142:606~609
Yunsuk Choi / 2021 / Treatment outcome and prognostic factors of Korean patients with chronic lymphocytic leukemia: a multicenter retrospective study / The Korean Journal of Internal Medicine 36(1):194~204
Dores GM / 2007 / Chronic lymphocytic leukaemia and small lymphocytic lymphoma : overview of the descriptive epidemiology / Br J Haematol 139:809~819
이혜원 / 2018 / Nationwide Statistical Analysis of Lymphoid Malignancies in Korea / Cancer Research and Treatment 50(1):222~238
Gunawardana C / 2008 / South Asian chronic lymphocytic leukaemia patients have more rapid disease progression in comparison to White patients / Br J Haematol 142:606~609
Yunsuk Choi / 2021 / Treatment outcome and prognostic factors of Korean patients with chronic lymphocytic leukemia: a multicenter retrospective study / The Korean Journal of Internal Medicine 36(1):194~204
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