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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 254 - 260 (7page)
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초록· 키워드
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Background: Grafts survive despite blood group antigens on the transplant being continuously exposed to antibodies in the blood of recipients in ABO-incompatible kidney transplantation (ABOi KT), owing to the mechanism of accommodation. We analyzed the immunodynamics of soluble ABH antigens in allografts from secretor donors and the influence of such immunodynamics on accommodation and subsequent graft survival in ABOi KT.
Methods: The genotype of a known human β-galactoside α-1,2-fucosyltransferase gene (FUT2), which determines soluble ABH antigen secretor status, was established in 32 donors for ABOi KT at the Severance Hospital, from June 2010 to July 2015. Clinical outcomes of recipients, such as anti-A/B antibody titer change, renal function, and graft survival, were evaluated.
Results: Twenty-five donors were secretors (78.1%), and seven were nonsecretors (21.9%). The frequency of anti-A/B IgG or IgM antibody titer elevation or reduction post-transplantation was not significantly related to donor secretor status. However, IgM titer was rapidly reduced in recipients transplanted from nonsecretor donors (P=0.01), which could be explained by the lack of absorption effect of soluble antigens, enhancing the binding of antibodies to antigens in the allografts. Interestingly, soluble ABH antigens did not affect rejection-free graft survival, which may be due to the nature of β-galactoside α-1,2-fucosyltransferase.
Conclusions: Soluble ABH antigens produced by transplanted kidneys from secretor donors played a role in inducing accommodation within three months of KT through neutralization; however, major graft outcomes were not affected.
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참고문헌 (25)
참고문헌 신청
Cosio FG / 2010 / Significance and implications of capillaritis during acute rejection of kidney allografts / Transplantation 89 : 1088 ~ 1094
Costa C / 2002 / Transgenic pigs designed to express human CD59 and H-transferase to avoid humoral xenograft rejection / Xenotransplantation 9 : 45 ~ 57
Fung MK / 2014 / Technical manual / American Association of Blood Banks
Kudo T / 1996 / Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese
Kumazaki T / 1984 / Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase / Proc Natl Acad Sci USA 81 : 4193 ~ 4197
Costa C / 2002 / Transgenic pigs designed to express human CD59 and H-transferase to avoid humoral xenograft rejection / Xenotransplantation 9 : 45 ~ 57
Fung MK / 2014 / Technical manual / American Association of Blood Banks
Kudo T / 1996 / Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese
Kumazaki T / 1984 / Biochemical evidence that secretor gene, Se, is a structural gene encoding a specific fucosyltransferase / Proc Natl Acad Sci USA 81 : 4193 ~ 4197
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