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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.2
- 수록면
- 18 - 26 (9page)
- DOI
- https://doi.org/10.3904/kjm.2020.95.1.18
이용수
초록· 키워드
오류제보하기
Kidney transplantation (KT) is the best way to improve the quality of life and survival of patients with end-stage renal disease.
However, after KT the adaptive immune system plays important roles in the development of rejection via multiple pathways.
Accordingly, the suppression or modulation of these pathways is key to allograft survival. Advances in our understanding of the immunology related to KT with the development of immunosuppressants have reduced the rate of acute rejection and improved short-term transplant outcomes. Nonetheless, de novo donor-specific antibodies and subsequent chronic rejection continue to be responsible for the poor long-term survival of transplanted patients. In addition, the morbidity and mortality rates in patients returning to dialysis after graft failure are high. Better long-term outcomes following KT require innovative treatment strategies that include a focus on de novo antibodies. Here, we review basic transplant immunology as well as the diagnostic tools and medications that contribute to successful KT. We also provide an update on newly developed immunosuppressants.
목차
등록된 정보가 없습니다.
참고문헌 (46)
참고문헌 신청
ESRD Registry Committee / Current renal replacement therapy in Korea 2019
Delmonico FL / 2011 / A call for government accountability to achieve national self-sufficiency in organ donation and transplantation / Lancet 378:1414~1418
Lin CM / 2016 / Direct and indirect allograft recognition : pathways dictating graft rejection mechanisms / Curr Opin Organ Transplant 21:40~44
Opelz G / 1997 / Impact of HLA compatibility on survival of kidney transplants from unrelated live donors / Transplantation 64:1473~1475
Tagliamacco A / 2014 / DQ molecules are the principal stimulators of de novo donor-specific antibodies in nonsensitized pediatric recipients receiving a first kidney transplant / Transpl Int 27:667~673
Delmonico FL / 2011 / A call for government accountability to achieve national self-sufficiency in organ donation and transplantation / Lancet 378:1414~1418
Lin CM / 2016 / Direct and indirect allograft recognition : pathways dictating graft rejection mechanisms / Curr Opin Organ Transplant 21:40~44
Opelz G / 1997 / Impact of HLA compatibility on survival of kidney transplants from unrelated live donors / Transplantation 64:1473~1475
Tagliamacco A / 2014 / DQ molecules are the principal stimulators of de novo donor-specific antibodies in nonsensitized pediatric recipients receiving a first kidney transplant / Transpl Int 27:667~673
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