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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제13권 제2호
- 발행연도
- 2015.1
- 수록면
- 150 - 156 (7page)
이용수
초록· 키워드
오류제보하기
Objective: Major depressive disorder (MDD) is projected to be a leading cause of disability globally by 2030. Only a minority of patients remit with antidepressants. If assay of polymorphisms influencing central nervous system (CNS) bioavailability could guide prescribers to more effectively dose patients, remission rates may improve and the burden of disease from MDD reduce.
Hepatic and blood brain barrier (BBB) polymorphisms appear to influence antidepressant CNS bioavailability.
Methods: A 12-week prospective double blind randomized genetically guided versus unguided trial of antidepressant dosing in Caucasian adults with MDD (n=148) was conducted.
Results: Subjects receiving genetically guided prescribing had a 2.52-fold greater chance of remission (95% confidence interval [CI]=1.71-3.73, z=4.66, p＜0.0001). The number needed to genotype (NNG)=3 (95% CI=1.7-3.5) to produce an additional remission.
Conclusion: These data suggest that a pharmacogenetic dosing report (CNSDoseⓇ) improves antidepressant efficacy. The effect size was sufficient that translation to clinical care may arise if results are independently replicated.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Amsterdam JD. / 1996 / Treatment algorithms in treatment-resistant depression / Psychiatr Clin North Am 19 : 371 ~ 386
Belmaker RH. / 2008 / Major depressive disorder / N Engl J Med 358 : 55 ~ 68
Domschke K. / 2014 / Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response / Int J Neuropsychopharmacol 17 : 1167 ~ 1176
Dutheil F. /
Fournier JC. / 2010 / Antidepressant drug effects and depression severity : a patient-level meta-analysis / JAMA 303 : 47 ~ 53
Belmaker RH. / 2008 / Major depressive disorder / N Engl J Med 358 : 55 ~ 68
Domschke K. / 2014 / Serotonin transporter gene hypomethylation predicts impaired antidepressant treatment response / Int J Neuropsychopharmacol 17 : 1167 ~ 1176
Dutheil F. /
Fournier JC. / 2010 / Antidepressant drug effects and depression severity : a patient-level meta-analysis / JAMA 303 : 47 ~ 53
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