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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제13권 제3호
- 발행연도
- 2015.1
- 수록면
- 250 - 255 (6page)
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초록· 키워드
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Objective: The multidrug resistance 1 (ABCB1, MDR1) gene, encoding P-glycoprotein, is extensively distributed and expressed in various tissues, such as a blood-brain barrier transporter. P-glycoprotein plays an important role in controlling the passage of substances between the blood and brain. The current study aimed to investigate possible associations of functional ABCB1 polymorphisms (C3435T, G2677T and C1236T) with response to antidepressant treatment and serum cortisol levels in Taiwanese patients with major depressive disorder (MDD).
Methods: We recruited 112 MDD patients who were randomized to fluoxetine (n=58, mean dose: 21.4±4.5 mg/day) or venlafaxine (n=54, 80.2±34.7 mg/day) treatment for 6 weeks. The 21-item Hamilton Depression Rating Scale (HDRS) was administered initially and biweekly after treatment, and cortisol levels were assessed initially and after 6-week antidepressant treatment.
Results: The initial HDRS scores and the HDRS scores after six weeks of antidepressant treatment were not significantly different among the different genotypes in each polymorphism of ABCB1. The percentage changes of HDRS scores over time were significantly different in the polymorphisms of ABCB1 G2677T (p=0.002). MDD patients with the G/G genotype of ABCB1 G2677T had a worse antidepressant treatment response. However, the polymorphisms of ABCB1 genotypes were not significantly associated with cortisol levels before and after antidepressant treatment in MDD patients.
Conclusion: The results suggested that the variants of ABCB1 may influence the short-term antidepressant response in MDD patients. Further details of the underlying mechanisms of ABCB1 in antidepressant treatment remain to be clarified.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Nakamura T. / 2009 / Effects of ABCB1 3435C>T genotype on serum levels of cortisol and aldosterone in women with normal menstrual cycles / Genet Mol Res 8:397~403
Tanabe M. / 2001 / Expression of P-glycoprotein in human placenta : relation to genetic polymorphism of the multidrug resistance(MDR)-1 gene / J Pharmacol Exp Ther 297:1137~1143
Sarginson JE. / 2010 / ABCB1(MDR1)polymorphisms and antidepressant response in geriatric depression / Pharmacogenet Genomics 20:467~475
Kato M. / 2008 / ABCB1(MDR1)gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder / Prog Neuropsychopharmacol Biol Psychiatry 32:398~404
Nikisch G. / 2008 / Citalopram enantiomers in plasma and cerebrospinal fluid of ABCB1 genotyped depressive patients and clinical response : a pilot study / Pharmacol Res 58:344~347
Tanabe M. / 2001 / Expression of P-glycoprotein in human placenta : relation to genetic polymorphism of the multidrug resistance(MDR)-1 gene / J Pharmacol Exp Ther 297:1137~1143
Sarginson JE. / 2010 / ABCB1(MDR1)polymorphisms and antidepressant response in geriatric depression / Pharmacogenet Genomics 20:467~475
Kato M. / 2008 / ABCB1(MDR1)gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder / Prog Neuropsychopharmacol Biol Psychiatry 32:398~404
Nikisch G. / 2008 / Citalopram enantiomers in plasma and cerebrospinal fluid of ABCB1 genotyped depressive patients and clinical response : a pilot study / Pharmacol Res 58:344~347
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