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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 89 - 95 (7page)
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초록· 키워드
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Piperlongumine (PL) is a natural product found in long pepper ( Piper longum ). The pharmacological effects of PL are well known, and it has been used for pain, hepatoprotection, and asthma in Oriental medicine. No studies have examined the effects of PL on bone tissue or bone-related diseases, including osteoporosis. The current study investigated for the first time the inhibitory effects of PL on osteoclast differentiation, bone resorption, and osteoclastogenesis-related factors in RAW264.7 macrophages stimulated by the receptor activator for nuclear factor- κB ligand (RANKL). Cytotoxicity was examined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and osteoclast differentiation and bone resorption were confirmed by tartrate-resistant acid phosphatase (TRAP) staining and pit formation analysis. Osteoclast differentiation factors were confirmed by western blotting. PL exhibited toxicity in RAW264.7 macrophages, inhibiting osteoclast formation and bone resorption, in addition to inhibiting the expression of osteoclastogenesis-related factors, such as tumor necrosis factor receptor-associated factor 6 (TRAF6), c-Fos, and NFATc1, in RANKL-stimulated RAW264.7 macrophages. These findings suggest that PL is suitable for the treatment of osteoporosis, and it serves as a potential therapeutic agent for various bone diseases.
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참고문헌 (27)
참고문헌 신청
D. J. HADJIDAKIS / 2006 / Bone Remodeling / Annals of the New York Academy of Sciences 1092(1):385~396
Qian-Yuan Wu / 2019 / Emerging role of circadian rhythm in bone remodeling / Journal of Molecular Medicine 97(1):19~24
Charles A. O'Brien / 2013 / Osteocyte control of osteoclastogenesis / Bone 54(2):258~263
Wellington J. Rody / 2001 / Osteoclast recruitment to sites of compression in orthodontic tooth movement / American Journal of Orthodontics and Dentofacial Orthopedics 120(5):477~489
Barrère F / 2006 / Bone regeneration : molecular and cellular interactions with calcium phosphate ceramics / Int J Nanomedicine 1:317~332
Qian-Yuan Wu / 2019 / Emerging role of circadian rhythm in bone remodeling / Journal of Molecular Medicine 97(1):19~24
Charles A. O'Brien / 2013 / Osteocyte control of osteoclastogenesis / Bone 54(2):258~263
Wellington J. Rody / 2001 / Osteoclast recruitment to sites of compression in orthodontic tooth movement / American Journal of Orthodontics and Dentofacial Orthopedics 120(5):477~489
Barrère F / 2006 / Bone regeneration : molecular and cellular interactions with calcium phosphate ceramics / Int J Nanomedicine 1:317~332
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