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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 96 - 101 (6page)
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초록· 키워드
오류제보하기
Norovirus, which causes gastroenteritis in humans, is an important food-borne pathogen worldwide. In an effort to discover an antiviral substance against norovirus, extracts from several seaweeds were evaluated for antiviral activity against feline calicivirus (FCV), which was used as a surrogate. The methanolic extract of Undaria pinnatifida exhibited the most significant antiviral activity and virucidal efficacy against FCV. The concentrations of the extract that reduced viral replication by 50% (EC50) and resulted in the death of 50% of the host cells (CC50) were 0.05 mg/mL and 1.02 mg/mL, respectively. The selectivity index, calculated from the ratio of the CC50 and EC50 was 20.4. No FCV infection of host cells occurred following a 1-h incubation in the presence of 12.50 mg/mL U. pinnatifida extract, indicating that the virus was completely inactivated by the extract treatment. The results obtained in this study will contribute to the development of a natural antiviral substance that will prevent food-borne disease caused by norovirus.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Barbosa JP / 2004 / In vitro antiviral diterpenes from the Brazilian brown alga Dictyota pfaffii / Planta Med 70 : 856 ~ 860
Bellamy K / 1995 / A review of the test methods used to establish virucidal activity / J Hosp Infect 30 : 389 ~ 396
Bidawid S / 2003 / A feline kidney cell line-based plaque assay for feline calicivirus, a surrogate for Norwalk virus / J Virol Methods 107 : 163 ~ 167
Blackburn BG / 2001 / Surveillance for waterborne-disease outbreaks asso-ciated with drinking water-United States / MMWR Surveillance Summaries 53 : 23 ~ 45
Blunt JW / 2006 / Marine natural products / Nat Prod Rep 23 : 26 ~ 78
Bellamy K / 1995 / A review of the test methods used to establish virucidal activity / J Hosp Infect 30 : 389 ~ 396
Bidawid S / 2003 / A feline kidney cell line-based plaque assay for feline calicivirus, a surrogate for Norwalk virus / J Virol Methods 107 : 163 ~ 167
Blackburn BG / 2001 / Surveillance for waterborne-disease outbreaks asso-ciated with drinking water-United States / MMWR Surveillance Summaries 53 : 23 ~ 45
Blunt JW / 2006 / Marine natural products / Nat Prod Rep 23 : 26 ~ 78
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굴과 상추에서 노로바이러스의 대체모델 feline calicivirus의 효율적 검출법 개발
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