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초록· 키워드
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Arsenic is an environmental pollutant and is known to induce toxicity. Arsenic acts on cells through a variety of mechanisms, influencing numerous signal transduction pathways. It induces a variety of cellular effects such as apoptosis, growth inhibition, promotion or inhibition of differentiation and angiogenesis. Arsenic has been associated with cancers of the skin, bladder, lung, kidney, and liver as well as with noncancerous conditions, diabetes and hepatopathy. However, arsenic trioxide (ATO) was reported to induce remission in patients with acute promyelocytic leukemia (APL). The anticancer efficiency of ATO was not restricted to APL; however, it has been extended to many solid tumors, including liver, cervical, prostate, lung, esophagus, and bladder tumors. Therefore, in this study, a number of previous studies are summarized that demonstrate arsenic-induced toxicity, including carcinogenesis and anticancer activity in vitro and in vivo. The arsenic metabolism that is involved in arsenic-induced toxicity is also discussed.
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참고문헌 (66)
참고문헌 신청
Aposhian HV / 1997 / Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity / Annu Rev Pharmacol Toxicol 37:397~419
Arnold LL / 2003 / Chronic studies evaluating the carcinogenicity of monomethylarsonic acid in rats and mice / Toxicology 190:197~219
Barchowsky A / 1999 / Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite / Free Radic Biol Med 27:1405~1412
Bhattacharyya R / 2003 / High arsenic groundwater: mobilization, metabolism and mitigation–an overview in the Bengal Delta Plain / Mol Cell Biochem 253:347~355
Bode AM / 2002 / The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects / Crit Rev Oncol Hematol 42:5~24
Arnold LL / 2003 / Chronic studies evaluating the carcinogenicity of monomethylarsonic acid in rats and mice / Toxicology 190:197~219
Barchowsky A / 1999 / Stimulation of reactive oxygen, but not reactive nitrogen species, in vascular endothelial cells exposed to low levels of arsenite / Free Radic Biol Med 27:1405~1412
Bhattacharyya R / 2003 / High arsenic groundwater: mobilization, metabolism and mitigation–an overview in the Bengal Delta Plain / Mol Cell Biochem 253:347~355
Bode AM / 2002 / The paradox of arsenic: molecular mechanisms of cell transformation and chemotherapeutic effects / Crit Rev Oncol Hematol 42:5~24
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