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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 311 - 324 (14page)
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초록· 키워드
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Arsenic is one of the most toxic environmental toxicants. More than 150 million people worldwide are exposed to arsenic through ground water contamination. It is an exclusive human carcinogen. Although the hallmarks of arsenic toxicity are skin lesions and skin cancers, arsenic can also induce cancers in the lung, liver, kidney, urinary bladder, and other internal organs. Arsenic is a non-mutagenic compound but can induce significant cytogenetic damage as measured by chromosomal aberrations, sister chromatid exchanges, and micronuclei formation in human systems. These genotoxic end points are extensively used to predict genotoxic potentials of different environmental chemicals, drugs, pesticides, and insecticides. These cytogenetic end points are also used for evaluating cancer risk. Here, by critically reviewing and analyzing the existing literature, we conclude that inorganic arsenic is a genotoxic carcinogen.
목차
Abstract
INTRODUCTION
GENOTOXIC POTENTIAL OF INORGANIC ARSENIC
GENOTOXICITY STUDIES OF INORGANIC ARSENIC ON HUMAN CELLS IN VITRO
GENOTOXICITY STUDIES OF INORGANIC ARSENIC ON HUMAN CELLS IN VIVO
CONCLUSIONS
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2018-513-003589356