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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: To mimic the muscle inspired cells adhesion through proteins secretion, the lamination of collagen–hydroxyapatite nanorod (nHA) composite nanofibers has been carried out successfully on polydopamine (PDA)-coated microfibrous polylactide-co-glycolide (PLGA) fabrics. The lamination of collagen-hydroxyapatite composite nanofibers on polydopamine-coated microfibrous PLGA fabrics was carried through electrospinning the solution of collagen containing L-glutamic acid-grafted hydroxyapatite nanorods (nHA-GA) at a flow rate of 1.5 mL/h and an applied voltage of 15 kV. Results: In comparison to pristine PLGA, dopamine-coated PLGA and collagen-hydroxyapatite composite nanofiber lamination has produced more wettable surfaces and surface wettability is found to higher with dopamine-coated PLGA fabrics then pristine PLGA. The SEM micrographs have clearly indicated that the lamination of polydopaminecoated PLGA fabric with collagen-hydroxyapatite composite nanofibers has shown increased adhesion of MC3T3E1 cells in comparison to pristine PLGA fabrics. Conclusion: The results of these studies have clearly demonstrated that collagen-nHA composites fibers may be used to create bioactive 3D scaffolds using PLGA as an architectural support agent.
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참고문헌 (24)
참고문헌 신청
Almasi D / 2016 / Preparation methods for improving PEEK’s Bioactivity for orthopedic and dental application : A review / Int J Biomater 2016 : 8202653 ~
Du YW / 2015 / In vitro and in vivo evaluation of bone morphogenetic protein-2 (BMP-2) immobilized collagencoated polyetheretherketone (PEEK) / Front Mater Sci 9 (1) : 38 ~
Erli HJ / 2006 / The effect of surface modification of a porous TiO2/perlite composite on the ingrowth of bone tissue in vivo / Biomaterials 27 : 1270 ~ 1276
Goodman SL / 1996 / Three-dimensional extracellular matrix textured biomaterials / Biomaterials 17 : 2087 ~ 2095
Haider A / 2014 / Morphological effects of HA on the cell compatibility of electrospun HA/PLGA composite nanofiber scaffolds / BioMed Research International
Du YW / 2015 / In vitro and in vivo evaluation of bone morphogenetic protein-2 (BMP-2) immobilized collagencoated polyetheretherketone (PEEK) / Front Mater Sci 9 (1) : 38 ~
Erli HJ / 2006 / The effect of surface modification of a porous TiO2/perlite composite on the ingrowth of bone tissue in vivo / Biomaterials 27 : 1270 ~ 1276
Goodman SL / 1996 / Three-dimensional extracellular matrix textured biomaterials / Biomaterials 17 : 2087 ~ 2095
Haider A / 2014 / Morphological effects of HA on the cell compatibility of electrospun HA/PLGA composite nanofiber scaffolds / BioMed Research International
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