지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 42 - 47 (6page)
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초록· 키워드
오류제보하기
Purpose: 5α reductase, dutasteride, has widely used to treat enlarged prostate (BPH). By suppressing
the conversion of testosterone to dihydrotestosterone it decreases serum prostate-specific antigen
(PSA) which is very important screening marker for prostate cancer. We evaluate the early serum
PSA changes after dutasteride treatment to Korean BPH patients.
Materials and Methods: A total 159 men with a clinical diagnosis of BPH and no evidence of
prostate cancer were enrolled. They were treated with dutasteride 0.5mg daily for 12 months. Serum
PSA was evaluated at 2, 6, and 12 months after the medication.
Result: Dutasteride statistically significantly reduced serum PSA to 0.70±0.52, 0.64±0.35, and
0.59±0.49 from baseline level at 2, 6, and 12 months after the medication, respectively. However,
there was no statistical significance among the three groups in serum PSA changes after dutasteride.
There were statistically significant correlations between a high pre-treatment serum PSA level and
a large reduction of follow-up PSA levels at 2, 6, and 12 months after dutasteride treatment.
Conclusions: The reduction of serum PSA is variable in patients to patients at 2, 6, and 12 months
after dutasteride treatment. The patient with high initial serum PSA revealed a large reduction
of serum PSA level after treatment. The traditional concept that follow-up serum PSA level should
be doubled for prostate cancer screening may overestimate real serum PSA level within 12 months
in Korean men receiving 5α reductase inhibitors. (J Korean Continence Soc 2008;12:42-47)
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Andriole G / 2005 / The effects of 5alpha-reductase inhibitors on the natural history, detection and grading of prostate cancer: current state of knowledge / J Urol 174 : 20
Andriole G. / 2005 / The effects of 5alpha-reductase inhibitors on the natural history, detection and grading of prostate cancer: current state of knowledge / J Urol 174 : 20
Ba?ar MM. / 2001 / The efficacy of alfuzosin treatment in patients with prostatism / Int Urol Nephrol 33 : 493 ~ 7
Brawer MK. / 1999 / Effect of finasteride and/or terazosin on serum PSA: results of VA Cooperative Study #359 / Prostate : 234 ~ 9
Carson C 3rd / 2003 / Rittmaster R. The role of dihydrotestosterone in benign prostatic hyperplasia / Urology 61 (4) : 2 ~ 7
Andriole G. / 2005 / The effects of 5alpha-reductase inhibitors on the natural history, detection and grading of prostate cancer: current state of knowledge / J Urol 174 : 20
Ba?ar MM. / 2001 / The efficacy of alfuzosin treatment in patients with prostatism / Int Urol Nephrol 33 : 493 ~ 7
Brawer MK. / 1999 / Effect of finasteride and/or terazosin on serum PSA: results of VA Cooperative Study #359 / Prostate : 234 ~ 9
Carson C 3rd / 2003 / Rittmaster R. The role of dihydrotestosterone in benign prostatic hyperplasia / Urology 61 (4) : 2 ~ 7
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