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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 873 - 878 (6page)
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초록· 키워드
오류제보하기
To assess whether the free-to-total prostate specific antigen (PSA) ratio (F/T PSA ratio) would enhance prostate cancer detection in Korean men with serum total PSA levels between 4 and 20ng/ml. Methods: A total of 240 consecutive patients whose serum PSA levels were between 4 and 20ng/ml were enrolled in this two-year study. All patients underwent ultrasound-guided transrectal biopsies of the prostate gland. The F/T PSA ratio was measured using the Roche immunoassay. Results: Of the 240 patients, 202 (84%) had benign histologies, while 38 (16%) had prostate cancer. The two patient groups were well matched for age. The mean F/T PSA ratio showed a statistically significant difference between the two groups: in the benign histology group it was 0.14 (0.04-0.37), and 0.10 (0.08-0.20) in the prostate cancer group (p<0.05). Out of the 183 patients with a PSA level between 4-10ng/ml, the mean F/T PSA ratios were 0.14 and 0.11 in the benign histology (n=158) and prostate cancer groups (n=25), respectively (p<0.05). From the 57 patients with a PSA level between 10-20ng/ml, the mean F/T PSA ratios were 0.14 and 0.10 in the benign histology (n=44) and prostate cancer groups (n=13), respectively (p<0.05). Overall, when the cut-off value of the F/T PSA ratio was 0.10, the sensitivity and specificity were 75.0% and 76.5%, while for the cut-off value of 0.15 they were 83.3% and 39.7% respectively. Conclusion: Our data demonstrated the usefulness of the free to total PSA ratio in distinguishing benign prostate disease and cancer disease, hence eliminating unnecessary biopsies. It is recommended that a cut-off value for the F/T PSA ratio of 0.10 be applied to Korean men which this is lower than the value used in Western countries.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
/ 1991 / Prostate specific antigen: a critical assessment of the most useful tumor marker for adenocarcinoma of the prostate 145 : 907 ~ 923
/ 1992 / Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer 147 : 815 ~ 816
/ 1992 / Prostate specific antigen predominantly forms a complex with a1- antichymotrypsin in blood. Implications for procedures to measure prostate specific antigen in seru
/ 1992 / Serum prostate specific antigen as prescreening test for prostate cancer 147 : 846 ~ 851
/ 1992 / The use of prostate specific antigen density to enhance the predictive value of intermediate levels of serum prostate specific antigen 147 : 817 ~ 821
/ 1992 / Prostate specific antigen density: a means of distinguishing benign prostatic hypertrophy and prostate cancer 147 : 815 ~ 816
/ 1992 / Prostate specific antigen predominantly forms a complex with a1- antichymotrypsin in blood. Implications for procedures to measure prostate specific antigen in seru
/ 1992 / Serum prostate specific antigen as prescreening test for prostate cancer 147 : 846 ~ 851
/ 1992 / The use of prostate specific antigen density to enhance the predictive value of intermediate levels of serum prostate specific antigen 147 : 817 ~ 821
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