지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,185 - 1,191 (7page)
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초록· 키워드
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Purpose: Exclusive enteral nutrition (EEN) therapy effectively induces clinical remission in Crohn’s disease (CD). It remains unclear,however, whether partial enteral nutrition (PEN) can maintain remission. This study was performed to determine the abilitiesof oral EEN and oral PEN to induce and maintain clinical remission in pediatric patients with CD, respectively.
Materials and Methods: Pediatric patients with CD who received oral EEN at a single center in 2000–2014 were identified retrospectively.
Remission rates of the EEN and PEN during the 2 years study period were determined. Risk factors for EEN and PEN failure were identified.
Results: Of the 66 patients who started EEN, 61 (92%) completed the course. Clinical remission was achieved in 88% (58/66) of the patients. All 58 patients with remission continued with PEN: 43 (74%) were treatment adherent. The cumulative remission rates at 1 and 2 years were 67% and 52%, respectively. Differing from EEN, limited therapeutic efficacy of PEN was shown in severeCD patients. Female gender associated significantly with non-adherence.
Conclusion: Oral EEN and PEN effectively induced and maintained remission in a pediatric population. Non-adherence was a limiting factor in the success of therapy.
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참고문헌 (35)
참고문헌 신청
Puntis J / 1984 / Long term prognosis of Crohn’s disease with onset in childhood and adolescence / Gut 25:329~336
Turunen P / 2009 / Long-term health outcomes in pediatric inflammatory bowel disease: a population-based study / Inflamm Bowel Dis 15:56~62
Yamamoto T / 2007 / Impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal cytokines during remission in patients with Crohn’s disease: a prospective study / Inflamm Bowel Dis 13:1493~1501
Lichtenstein GR / 2004 / Remission in patients with Crohn’s disease is associated with improvement in employment and quality of life and a decrease in hospitalizations and surgeries / Am J Gastroenterol 99:91~96
Berni Canani R / 2006 / Short- and long-term therapeutic effcacy of nutritional therapy and corticosteroids in paediatric Crohn’s disease / Dig Liver Dis 38:381~387
Turunen P / 2009 / Long-term health outcomes in pediatric inflammatory bowel disease: a population-based study / Inflamm Bowel Dis 15:56~62
Yamamoto T / 2007 / Impacts of long-term enteral nutrition on clinical and endoscopic disease activities and mucosal cytokines during remission in patients with Crohn’s disease: a prospective study / Inflamm Bowel Dis 13:1493~1501
Lichtenstein GR / 2004 / Remission in patients with Crohn’s disease is associated with improvement in employment and quality of life and a decrease in hospitalizations and surgeries / Am J Gastroenterol 99:91~96
Berni Canani R / 2006 / Short- and long-term therapeutic effcacy of nutritional therapy and corticosteroids in paediatric Crohn’s disease / Dig Liver Dis 38:381~387
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