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논문 기본 정보

자료유형
학술저널
저자정보
Jang Sooyoung (Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Yonsei University Co) Kim Younjuong (Department of Medicine Yonsei University College of Medicine Seoul Korea.) Lee Changjun (Department of Medicine Yonsei University College of Medicine Seoul Korea.) Kwon Bomi (Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Yonsei University Co) Noh Jihye (Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Yonsei University Co) Jee Jai J. (Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Yonsei University Co) Yoon Sang Sun (Department of Microbiology and Immunology Brain Korea 21 Project for Medical Sciences Yonsei Univer) Koh Hong (Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Yonsei University Co) Park Sowon (Division of Gastroenterology Hepatology and Nutrition Department of Pediatrics Yonsei University Co)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.50
발행연도
2021.12
수록면
1 - 13 (13page)
DOI
10.3346/jkms.2021.36.e342

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Background: Exclusive enteral nutrition (EEN) induces remission in pediatric Crohn's disease (CD). The exact mechanism of EEN therapy in CD is unknown, but alteration of the intestinal microflora after EEN is thought to affect mucosal healing. To determine the link between EEN therapy and therapeutic efficacy in CD, we established a murine model of dextran sulfate sodium (DSS)-induced colitis and applied EEN therapy. Methods: Eight-week-old C57BL/6 mice were administered DSS for 4 days to induce colitis, and either normal chow (NC) or EEN was administered for the following 4 days. The mice were grouped according to the feeding pattern after DSS administration: DSS/NC and DSS/ EEN groups. The clinical course was confirmed via daily observation of the weight and stool. Fecal samples were collected and 16sRNA sequencing was used. The mice were sacrificed to confirm colonic histopathology. Results: Weight reduction and increase in disease activity were observed as the day progressed for 4 days after DSS administration. There was significant weight recovery and improvement in disease activity in the EEN group compared to that in the NC group. Verrucomicrobia and Proteobacteria abundances tended to increase and Bacteroidetes abundance decreased in the EEN group. In the EEN group, significant changes in the β-diversity of the microbiota were observed. In the analysis of microbiome species, abundances of Akkermansia muciniphila, Clostridium cocleatum, mucin-degrading bacteria, Flintibacter butyricus, and Parabacteroides goldsteinii, which are beneficial microbiota, were significantly increased in the EEN group compared to those in the NC group. More abundant mucins were confirmed in the colonic histopathology of the EEN group. These microbial and histopathological differences suggested that EEN might improve colitis symptoms in a murine colitis model by promoting mucin recycling and subsequently inducing the healing effect of the gut barrier. Conclusion: EEN showed clinical efficacy in a murine model of colitis. Based on the increase in mucin-degrading bacteria and the pathological increase in mucin production after EEN administration, it can be observed that mucin plays an important role in the therapeutic effect of EEN.
#Exclusive Enteral Nutrition #Murine Model #Mucin #Microbiome

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참고문헌 (40)

참고문헌 신청
Boyapati R / 2015 / Pathogenesis of Crohn’s disease / F1000Prime Rep 7:44 google schola Day AS / 2015 / Exclusive enteral nutrition in children with Crohn’s disease / World J Gastroenterol 21(22):6809~6816 google schola Ruemmele FM / 2014 / Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn’s disease / J Crohns Colitis 8(10):1179~1207 google schola Mustafa Adamji / 2019 / An overview of the role of exclusive enteral nutrition for complicated Crohn’s disease / Intestinal research 17(2):171~176 dbpia Bannerjee K / 2004 / Anti-inflammatory and growth-stimulating effects precede nutritional restitution during enteral feeding in Crohn disease / J Pediatr Gastroenterol Nutr 38(3):270~275 google schola

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