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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 775 - 782 (8page)
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초록· 키워드
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Purpose: This study was undertaken to investigate the outcomes associated with docetaxel treatment of Korean patients with hormone-refractory prostate cancer (HRPC) and to compare its clinical efficacies in 1st and 2nd-line settings. Patients and Methods: This study was retrospectively performed and included 47 patients with HRPC. The 1st-line group consisted of 19 patients who had not undergone prior chemotherapy, and the 2nd-line group consisted of 28 patients who underwent prior chemotherapy. All patients were treated with 75mg/m2 IV docetaxel every 3 weeks and 5mg of prednisone twice daily with a continuous androgen blockade. Results: Of 47 study subjects, 14 patients (29.8%) had ≥50% PSA decline from baseline. PSA response was more common in the 1st-line group, but this was not statistically different (42.1% vs. 21.4%, p=0.114). After a median follow up of 11 months (range, 6-24 months), the 1st-line group showed a longer time to PSA progression (4 vs. 2 months, p=0.015) and survival (17 vs. 10 months, p=0.037) than the 2nd-line group. In terms of toxicities, no difference was apparent between the 2 groups. Conclusion: In a 1st-line setting, docetaxel is an effective and tolerable agent for Korean HRPC patients, and that its efficacy is limited, although 2nd-line docetaxel is tolerable.
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참고문헌 (21)
참고문헌 신청
Akaza H / 2007 / The 5th conference on Asian Trends in prostate cancer hormone therapy / Asian Pac J Cancer Prev 8 : 3 ~ 12
Berthold DR / 2005 / Management of advanced prostate cancer after first-line chemotherapy / J Clin Oncol 23 : 8247 ~ 8252
Calabro F / 2007 / Current indications for chemotherapy in prostate cancer patients / Eur Urol 51 : 17 ~ 26
Crawford ED / 1989 / A controlled trial of leuprolide with and without flutamide in prostatic carcinoma / N Engl J Med 321 : 419 ~ 424
Diaz JF / 1993 / Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition / Biochemistry 32 : 2
Berthold DR / 2005 / Management of advanced prostate cancer after first-line chemotherapy / J Clin Oncol 23 : 8247 ~ 8252
Calabro F / 2007 / Current indications for chemotherapy in prostate cancer patients / Eur Urol 51 : 17 ~ 26
Crawford ED / 1989 / A controlled trial of leuprolide with and without flutamide in prostatic carcinoma / N Engl J Med 321 : 419 ~ 424
Diaz JF / 1993 / Assembly of purified GDP-tubulin into microtubules induced by taxol and taxotere: reversibility, ligand stoichiometry, and competition / Biochemistry 32 : 2
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