지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 505 - 511 (7page)
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초록· 키워드
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Purpose: Behçet’s disease (BD) is a disease of unknown etiology, which has multisystemic involvement. This
multisystemic involvement might be the clue for an autoimmune pathogenesis. In order to evaluate an autoimmune
pathogenesis, we examined immunoreactans depositions in the skin of BD patients. Materials and Methods: The
skin samples of 108 BD patients (28 perilesional skin, 44 positive pathergy test site, 22 negative pathergy test site,
14 normal skin) were examined for the depositions of immunoglobulin (Ig)M, IgG, IgA, complement 3 (C3), and
fibrinogen (F) using direct immunofluorescence (DIF). The data were statistically compared to the DIF of 36
systemic lupus erythematosus (SLE) patients and 20 healthy controls using χ2 Fisher exact test. Results: Highly
significant immunoreactans depositions were obtained in BD (deposition rates: IgM 70.3%, IgG 0%, IgA 20.3%, C3
62.9%, F 83.3%). The comparison with SLE revealed no differences in IgM, IgA, and C3. However, IgG deposition
was higher in SLE while F deposition was higher in BD. In both BD and SLE, the Ig depositions were highly
significant when the data were compared with the healthy controls. Conclusion: The significant deposition of
immunoreactans in BD, especially in the negative pathergy and the normal skin sites, were observed. This study is
the first controlled study revealing positive Ig depositions in BD, and it is expected to help us to reconsider the
autoimmune pathogenesis in BD.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Akdag KOSE A / 1997 / importance of direct immunofluorescence in the diagnosis of lupus erythematosus / Turkderm 31 : 114 ~ 116
Akdag Kose A / 1996 / Behcet hastalarlnda Pategy pozitif, negative, lezyonlu ve lezyonsuz deride histopatolojik ve immunfloresan bulgularln karsilastirilmasl. XV. National Dermatology
Alpsoy E / 2003 / Histological and immunofluorescence findings of non-follicular papulopustular lesions in patients with Behcet’s disease / J Eur Acad Dermatol Venereol 17
Amital H / 1999 / Autoimmunity and autoimmune disease such as systemic lupus erythematosus / Academic Press : 1 ~ 16
Azizlerli G / 1977 / Major immunoglobulins in Behcet’s disease and a study with direct and indirect immunofluorescent methods / Excepta Medica. International Congress Series
Akdag Kose A / 1996 / Behcet hastalarlnda Pategy pozitif, negative, lezyonlu ve lezyonsuz deride histopatolojik ve immunfloresan bulgularln karsilastirilmasl. XV. National Dermatology
Alpsoy E / 2003 / Histological and immunofluorescence findings of non-follicular papulopustular lesions in patients with Behcet’s disease / J Eur Acad Dermatol Venereol 17
Amital H / 1999 / Autoimmunity and autoimmune disease such as systemic lupus erythematosus / Academic Press : 1 ~ 16
Azizlerli G / 1977 / Major immunoglobulins in Behcet’s disease and a study with direct and indirect immunofluorescent methods / Excepta Medica. International Congress Series
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