지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 624 - 629 (6page)
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초록· 키워드
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Purpose: To evaluate prospectively the role of prostate-specific antigen (PSA) density in predicting Gleason score upgrading in prostate cancer patients eligible for active surveillance (T1/T2, biopsy Gleason score≤6, PSA≤10 ng/mL, and ≤2 positive biopsy cores). Materials and Methods: Between January 2010 and November 2013, among patients who underwent greater than 10-core transrectal ultrasound-guided biopsy, 60 patients eligible for active surveillance underwent radical prostatectomy. By use of the modified Gleason criteria, the tumor grade of the surgical specimens was examined and compared with the biopsy results. Results: Tumor upgrading occurred in 24 patients (40.0%). Extracapsular disease and positive surgical margins were found in 6 patients (10.0%) and 8 patients (17.30%), respectively. A statistically significant correlation between PSA density and postoperative upgrading was found (p=0.030); this was in contrast with the other studied parameters, which failed to reach significance, including PSA, prostate volume, number of biopsy cores, and number of positive cores. Tumor upgrading was also highly associated with extracapsular cancer extension (p=0.000). The estimated optimal cutoff value of PSA density was 0.13 ng/mL2, obtained by receiver operating characteristic analysis (area under the curve=0.66; p=0.020; 95% confidence interval, 0.53-0.78). Conclusions: PSA density is a strong predictor of Gleason score upgrading after radical prostatectomy in patients eligible for active surveillance. Because tumor upgrading increases the potential for postoperative pathological adverse findings and prognosis, PSA density should be considered when treating and consulting patients eligible for active surveillance.
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등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Klotz L / 2010 / Clinical results of long-term follow-up of a large, active surveillance cohort with localized prostate cancer / J Clin Oncol 28:126~131
Steinberg DM / 1997 / Correlation of prostate needle biopsy and radical prostatectomy Gleason grade in academic and community settings / Am J Surg Pathol 21:566~576
Cookson MS / 1997 / Correlation between Gleason score of needle biopsy and radical prostatectomy specimen: accuracy and clinical implications / J Urol 157:559~562
Kvale R / 2009 / Concordance between Gleason scores of needle biopsies and radical prostatectomy specimens: a population-based study / BJU Int 103:1647~1654
Thickman D / 1996 / Effect of the number of core biopsies of the prostate on predicting Gleason score of prostate cancer / J Urol 156:110~113
Steinberg DM / 1997 / Correlation of prostate needle biopsy and radical prostatectomy Gleason grade in academic and community settings / Am J Surg Pathol 21:566~576
Cookson MS / 1997 / Correlation between Gleason score of needle biopsy and radical prostatectomy specimen: accuracy and clinical implications / J Urol 157:559~562
Kvale R / 2009 / Concordance between Gleason scores of needle biopsies and radical prostatectomy specimens: a population-based study / BJU Int 103:1647~1654
Thickman D / 1996 / Effect of the number of core biopsies of the prostate on predicting Gleason score of prostate cancer / J Urol 156:110~113
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