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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 951 - 960 (10page)
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초록· 키워드
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Purpose: In epidemiologic and animal studies, a high fat diet (HFD) has been shown to be associated with lower bone mineral density (BMD) and a higher risk of osteoporotic fractures. Meanwhile, consuming a HFD containing diacylglycerol (DAG) instead of triacylglycerol (TAG) is known to offer metabolically beneficial effects of reductions in body weight and abdominal fat. The purpose of this study was to investigate the effects of a HFD containing DAG (HFD-DAG) on bone in mice. Materials and Methods: Four-week-old male C57BL/6J mice (n=39) were divided into three weight-matched groups based on diet type: a chow diet group, a HFD containing TAG (HFD-TAG) group, and a HFD-DAG group. After 20 weeks, body composition and bone microstructure were analyzed using dual energy X-ray absorptiometry and micro-computed tomography. Reverse transcription-polymerasechain reaction (PCR) and real-time PCR of bone marrow cells were performedto investigate the expressions of transcription factors for osteogenesis or adipogenesis.
Results: The HFD-DAG group exhibited lower body weight, higher BMD, and superior microstructural bone parameters, compared to the HFD-TAG group. The HFD-DAG group showed increased expression of Runx2 and decreasedexpression of PPARγ in bone marrow cells, compared to the HFD-TAG group. The HFD-DAG group also had lower levels of plasma glucose, insulin, total cholesterol, and triglyceride than the HFD-TAG group. Conclusion: Compared to HFD-TAG, HFD-DAG showed beneficial effects on bone and bone metabolism in C57BL/6J mice.
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참고문헌 (24)
참고문헌 신청
[학술지(정기간
Baek KH / 2010 / Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cult
Basu S / 2001 / Association between oxidative stress and bone mineral density / Biochem Biophys Res Commun 288 : 275 ~ 279
Bielohuby M / 2010 / Short-term exposure to low-carbohydrate, high-fat diets induces low bone mineral density and reduces bone formation in rats / J Bone Miner Res 25 : 275 ~
Cao JJ / 2009 / High-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in the tibia in mice / Bone 44 : 1097 ~ 1104
Baek KH / 2010 / Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cult
Basu S / 2001 / Association between oxidative stress and bone mineral density / Biochem Biophys Res Commun 288 : 275 ~ 279
Bielohuby M / 2010 / Short-term exposure to low-carbohydrate, high-fat diets induces low bone mineral density and reduces bone formation in rats / J Bone Miner Res 25 : 275 ~
Cao JJ / 2009 / High-fat diet decreases cancellous bone mass but has no effect on cortical bone mass in the tibia in mice / Bone 44 : 1097 ~ 1104
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