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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제5호
- 발행연도
- 2019.1
- 수록면
- 335 - 344 (10page)
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Obesity causes inflammation and impairs thermogenic functions in brown adipose tissue (BAT). The adipokine lipocalin 2 (LCN2) has been implicated in inflammation and obesity. Herein, we investigated the protective effects of caloric restriction (CR) on LCN2-mediated inflammation and oxidative stress in the BAT of high-fat diet (HFD)-fed mice. Mice were fed a HFD for 20 weeks and then either continued on the HFD or subjected to CR for the next 12 weeks. CR led to the browning of the white fat-like phenotype in HFD-fed mice. Increased expressions of LCN2 and its receptor in the BAT of HFD-fed mice were significantly attenuated by CR. Additionally, HFD+CR-fed mice had fewer neutrophils and macrophages expressing LCN2 and iron-positive cells than HFD-fed mice. Further, oxidative stress and mitochondrial fission induced by a HFD were also significantly attenuated by CR. Our findings indicate that the protective effects of CR on inflammation and oxidative stress in the BAT of obese mice may be associated with regulation of LCN2.
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참고문헌 (47)
참고문헌 신청
Farmer SR / 2008 / Molecular determinants of brown adipocyte formation and function / Genes Dev 22:1269~1275
Parker N / 2009 / Uncoupling protein-1(UCP1)contributes to the basal proton conductance of brown adipose tissue mitochondria / J Bioenerg Biomembr 41:335~342
Alcalá M / 2017 / Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice / Sci Rep 7:16082
Lowell BB / 1993 / Development of obesity in transgenic mice after genetic ablation of brown adipose tissue / Nature 366:740~742
Franssens BT / 2017 / Relation between brown adipose tissue and measures of obesity and metabolic dysfunction in patients with cardiovascular disease / J Magn Reson Imaging 46:497~504
Parker N / 2009 / Uncoupling protein-1(UCP1)contributes to the basal proton conductance of brown adipose tissue mitochondria / J Bioenerg Biomembr 41:335~342
Alcalá M / 2017 / Increased inflammation, oxidative stress and mitochondrial respiration in brown adipose tissue from obese mice / Sci Rep 7:16082
Lowell BB / 1993 / Development of obesity in transgenic mice after genetic ablation of brown adipose tissue / Nature 366:740~742
Franssens BT / 2017 / Relation between brown adipose tissue and measures of obesity and metabolic dysfunction in patients with cardiovascular disease / J Magn Reson Imaging 46:497~504
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