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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: The objective of this study is to develop a new animal model with Kidney-hypofunction for Sasang Constitutional Medicine, especially for partial Soyangin(one of four constitution which has good digestive function and poor renal function) by Unilateral Ureteral Obstruction ,and to estimate the factor related to obesity, dyslipidemia, and metabolic syndrome.
Methods: The C57BL/6J mice were divided into 3 groups : normal group, high fat diet(HFD) control group, and HFD group with Unilateral Ureteral Obstruction(UUO). Then, the HFD control group and the experimental group were fed with high fat diet for 6 weeks. Food intake and body weight were measured at regular time by week. After the final experiment, blood was gathered for bloodchemical examination and organs(liver, fatty tissue) were remoed, weighted, and mRNA was analyzed with real-time PCR.
Results: The weight growth rate with High fat diet went down by 8.35% in experimental group and had similar FER with the normal group, while HFD control group had higher weight growth rate and FER than any other groups. Also The experimental group had lower triglyceride and LDL cholesterol rate and higher glucose rate in serum. and in mRNA expression, GLUT-9, the protein related to excretion of uric acid and metabolic syndrome, expressed lower rate than that of HFD control group. and IL-6, a kind of cytokine related to obesity and metabolic syndrome, expressed more than HFD control group.
Conclusions: It was found that Kidney-hypofunction animal-experimental model is susceptible to metabolic syndrome.
Methods: The C57BL/6J mice were divided into 3 groups : normal group, high fat diet(HFD) control group, and HFD group with Unilateral Ureteral Obstruction(UUO). Then, the HFD control group and the experimental group were fed with high fat diet for 6 weeks. Food intake and body weight were measured at regular time by week. After the final experiment, blood was gathered for bloodchemical examination and organs(liver, fatty tissue) were remoed, weighted, and mRNA was analyzed with real-time PCR.
Results: The weight growth rate with High fat diet went down by 8.35% in experimental group and had similar FER with the normal group, while HFD control group had higher weight growth rate and FER than any other groups. Also The experimental group had lower triglyceride and LDL cholesterol rate and higher glucose rate in serum. and in mRNA expression, GLUT-9, the protein related to excretion of uric acid and metabolic syndrome, expressed lower rate than that of HFD control group. and IL-6, a kind of cytokine related to obesity and metabolic syndrome, expressed more than HFD control group.
Conclusions: It was found that Kidney-hypofunction animal-experimental model is susceptible to metabolic syndrome.
목차
서론
실험방법
결과
고찰
결론
참고문헌
참고문헌 (33)
참고문헌 신청
Lee JM / 2003 / Dongeisusebowon / Yeogang :36;278
Hwang MW / 2012 / The lecture of Sasang constitution / Koonja :33~40
Dept. of Sasang Constitutional Medicine. All colleges of Korean med. in Korea(compilation) / 2012 / The revised and enlarged Sasang Constitutional Medicine / Jipmoondang :136~144
황민우 / 2009 / 少陽人 病理論에 관한 考察 / 사상체질의학회지 21(3):1~16
Lalich, J. J. / 1975 / Protein overload nephropathy in rats with unilateral nephrectomy. A correlative light immunogluorescence and electron microscopical analysis / Archives of pathology 99(2):72~79
Hwang MW / 2012 / The lecture of Sasang constitution / Koonja :33~40
Dept. of Sasang Constitutional Medicine. All colleges of Korean med. in Korea(compilation) / 2012 / The revised and enlarged Sasang Constitutional Medicine / Jipmoondang :136~144
황민우 / 2009 / 少陽人 病理論에 관한 考察 / 사상체질의학회지 21(3):1~16
Lalich, J. J. / 1975 / Protein overload nephropathy in rats with unilateral nephrectomy. A correlative light immunogluorescence and electron microscopical analysis / Archives of pathology 99(2):72~79
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