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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 311 - 318 (8page)
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초록· 키워드
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Vitamin C (ascorbic acid) supplementation has been suggested to negatively correlate with obesity in humans and other animals. Previous studies, including ours, have demonstrated that a high-fat diet (HFD) induces obesity and related diseases such as hyperlipidemia, hyperglycemia, insulin resistance, and nonalcoholic fatty liver disease. Here, we investigated the effects of vitamin C on visceral adipocyte hypertrophy and glucose intolerance in C57BL/6J mice. Mice received a low-fat diet (LFD, 10% kcal fat), HFD (45% kcal fat), or the same HFD supplemented with vitamin C (HFD-VC, 1% w/w) for 15 weeks. Visceral adiposity and glucose intolerance were examined using metabolic measurements, histology, and gene expression analyses. Mice in the HFD-VC supplementation group had reduced body weight, mesenteric fat mass, and mesenteric adipocyte size compared with HFD-fed mice. Vitamin C intake in obese mice also decreased the mRNA levels of lipogenesis-related genes (i.e., stearoyl-CoA desaturase 1 and sterol regulatory element-binding protein 1c) in mesenteric adipose tissues, inhibited hyperglycemia, and improved glucose tolerance. In addition, vitamin C attenuated the HFD-induced increase in the size of pancreatic islets. These results suggest that vitamin C suppresses HFD-induced visceral adipocyte hypertrophy and glucose intolerance in part by decreasing the visceral adipose expression of genes involved in lipogenesis.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (33)
참고문헌 신청
[학술지(정기간행물)] - Abdel-Wahab YH / 2002 / Vitamin C supplementation decreases insulin glycation and improves glucose homeostasis in obese hyperglycemic (ob/ob)mice / Metabolism 51 : 514 ~ 517
[학술지(정기간행물)] - Ahrén J / 2010 / Increased β-cell volume in mice fed a high-fat diet: a dynamic study over 12 months / Islets 2 : 353 ~ 356
[학술지(정기간행물)] - Ahrén B / 2002 / Insufficient islet compensation to insulin resistance vs. reduced glucose effectiveness in glucose-intolerant mice / American Journal of Physiology. Endocrinology and Metabolism 283 : E738- ~ E744
[학술지(정기간행물)] - Ashor AW / 2017 / Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials / European Journal of Clinical Nutrition 71 : 1371 ~ 1380
[학술지(정기간행물)] - Campión J / 2006 / Diferential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity / Journal of Physiology and Biochemistry 62 : 71 ~ 80
[학술지(정기간행물)] - Ahrén J / 2010 / Increased β-cell volume in mice fed a high-fat diet: a dynamic study over 12 months / Islets 2 : 353 ~ 356
[학술지(정기간행물)] - Ahrén B / 2002 / Insufficient islet compensation to insulin resistance vs. reduced glucose effectiveness in glucose-intolerant mice / American Journal of Physiology. Endocrinology and Metabolism 283 : E738- ~ E744
[학술지(정기간행물)] - Ashor AW / 2017 / Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials / European Journal of Clinical Nutrition 71 : 1371 ~ 1380
[학술지(정기간행물)] - Campión J / 2006 / Diferential gene expression and adiposity reduction induced by ascorbic acid supplementation in a cafeteria model of obesity / Journal of Physiology and Biochemistry 62 : 71 ~ 80
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UCI(KEPA) : I410-ECN-0101-2019-510-000302863