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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 797 - 807 (11page)
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초록· 키워드
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Mast cells have been regarded for a long time as effector cells in IgE mediated type I reactions and in host defence against parasites. However, they are resident in all environmental exposed tissues and express a wide variety of receptors, suggesting that these cells can also function as sentinels in innate immune responses.
Indeed, studies have demonstrated an important role of mast cells during the induction of life-saving antibacterial responses. Furthermore, recent findings have shown that mast cells promote and modulate the development of adaptive immune responses, making them an important hinge of innate and acquired immunity. In addition, mast cells and several mast cell-produced mediators have been shown to be important during the development of allergic airway diseases. In the present review, we will summarize findings on the role of mast cells during the development of adaptive immune responses and highlight their function, especially during the development of allergic asthma.
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참고문헌 (25)
참고문헌 신청
[학술지(
Daeron M / 1995 / Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors / J Clin Invest 95 : 577 ~ 585
Daeron M / 1995 / The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activati
Enerback L / 1986 / Intraepithelial migration of nasal mucosal mast cells in hay fever / Int Arch Allergy Appl Immunol 80 : 44 ~ 51
Galli SJ / 2005 / Mast cells as “tunable” effector and immunoregulatory cells: recent advances / Annu Rev Immunol 23 : 749 ~ 786
Daeron M / 1995 / Regulation of high-affinity IgE receptor-mediated mast cell activation by murine low-affinity IgG receptors / J Clin Invest 95 : 577 ~ 585
Daeron M / 1995 / The same tyrosine-based inhibition motif, in the intracytoplasmic domain of Fc gamma RIIB, regulates negatively BCR-, TCR-, and FcR-dependent cell activati
Enerback L / 1986 / Intraepithelial migration of nasal mucosal mast cells in hay fever / Int Arch Allergy Appl Immunol 80 : 44 ~ 51
Galli SJ / 2005 / Mast cells as “tunable” effector and immunoregulatory cells: recent advances / Annu Rev Immunol 23 : 749 ~ 786
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