지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 923 - 927 (5page)
이용수
초록· 키워드
오류제보하기
Purpose: Up to 71% of South Korean postmenopausal women have vitamin D deficiency {serum 25-hydroxyvitamin D [25(OH)D] level <50 nmol/L}. Data on vitamin D supplementation was collected during the screening phase of an efficacy/safety study of denosumab in Korean postmenopausal women with osteoporosis. This report describes the effect of vitamin D supplementation on repletion to 25(OH)D levels ≥50 nmol/L in Korean postmenopausal women with osteoporosis.
Materials and Methods: Vitamin D levels of Korean postmenopausal women (60–90 years old) were measured by extracting 25(OH)D2 and 25(OH)D3 from serum samples via protein precipitation and using liquid chromatography with tandem mass spectrometry detection. Calibration curves were constructed from the mass chromatograms to obtain total vitamin D levels. Subjectswith serum 25(OH)D levels <50 nmol/L were supplemented with 1000 IU of vitamin D tablets during the 2.5-month-long screening period. Dose, frequency, and duration were determined by the investigator. If repletion was achieved (≥50 nmol/L) on retest, subjects were eligible to be rescreened for study entry.
Results: Of 371 subjects screened, 191 (52%) required vitamin D supplementation, and 88% (168 of 191) were successfully repleted. More than half of the subjects (58%) who were successfully repleted received doses of 2000 IU daily. The mean time to successful repletion was 31 days (standard deviation 8.4 days; range 11–48 days).
Conclusion: Supplementation with daily median doses of 2000 IU vitamin D successfully repleted 88% of Korean postmenopausalwomen with osteoporosis within 48 days to a serum vitamin D level of 50 nmol/L.
목차
등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Watts NB / 2010 / American Association of Clinical Endocrinologists Medical Guidelines for Clinical Practice for the diagnosis and treatment of postmenopausal osteoporosis / Endocr Pract 16(Suppl 3):1~37
Prentice RL / 2013 / Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study / Osteoporos Int 24:567~580
Bischoff-Ferrari HA / 2012 / A pooled analysis of vitamin D dose requirements for fracture prevention / N Engl J Med 367:40~49
홍희옥 / 2013 / Effects of calcium intake, milk and dairy product intake, and blood vitamin D level on osteoporosis risk in Korean adults: analysis of the 2008 and 2009 Korea National Health and Nutrition Examination Survey / Nutrition Research and Practice 7(5):409~417
Lips P / 2006 / The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation / J Intern Med 260:245~254
Prentice RL / 2013 / Health risks and benefits from calcium and vitamin D supplementation: Women’s Health Initiative clinical trial and cohort study / Osteoporos Int 24:567~580
Bischoff-Ferrari HA / 2012 / A pooled analysis of vitamin D dose requirements for fracture prevention / N Engl J Med 367:40~49
홍희옥 / 2013 / Effects of calcium intake, milk and dairy product intake, and blood vitamin D level on osteoporosis risk in Korean adults: analysis of the 2008 and 2009 Korea National Health and Nutrition Examination Survey / Nutrition Research and Practice 7(5):409~417
Lips P / 2006 / The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation / J Intern Med 260:245~254
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Korean Society for Bone and Mineral Research Task Force Report: Perspectives on Intermittent High-dose Vitamin D Supplementation
대한골대사학회지
2017 .08
-
The Big Vitamin D Mistake
예방의학회지
2017 .07
-
비타민D의 보충요법
대한의사협회지
2017 .01
-
The Effect of Education and Vitamin D Supplementation on the Achievement of Optimal Vitamin D Level in Korean Postmenopausal Women
대한골대사학회지
2019 .01
-
Should We Measure Vitamin D Level?
Acute and Critical Care
2016 .01
-
Practical Vitamin D Supplementation Using Machine Learning
대한골대사학회지
2020 .01
-
Increment in vitamin D level and bone mineral accrual in children with vitamin D deficiency
Korean journal of pediatrics
2016 .01
-
Effects of Bazedoxifene/Vitamin D Combination Therapy on Serum Vitamin D Levels and Bone Turnover Markers in Postmenopausal Women with Osteopenia: A Randomized Controlled Trial
대한골대사학회지
2023 .05
-
Position Statement: Vitamin D Intake to Prevent Osteoporosis and Fracture in Adults
대한골대사학회지
2022 .11
-
Vitamin D and COVID-19: Is something better than nothing?
Osteoporosis and Sarcopenia
2020 .01
-
Calcium and Vitamin D Supplementations: 2015 Position Statement of the Korean Society for Bone and Mineral Research
대한골대사학회지
2015 .01
-
Effect of multivitamin on serum 25-hydroxy vitamin D level in postmenopausal women: A randomized, double-blind, placebo-controlled trial
Osteoporosis and Sarcopenia
2016 .01
-
The relationship between serum vitamin D levels and sleep quality in fixed day indoor field workers in the electronics manufacturing industry in Korea
대한직업환경의학회지
2017 .07
-
Vitamin D and the Immune System in Menopause: A Review
대한폐경학회지
2021 .12
-
The Role of Vitamin D in Menopausal Medicine
고신대학교 의과대학 학술지
2016 .01
-
The effect of metformin on vitamin B12 level in pediatric patients
Annals of Pediatirc Endocrinology & Metabolism
2022 .09
-
Maintenance Dose of Vitamin D: How Much Is Enough?
대한골대사학회지
2018 .01
-
Effect of Vitamin D Supplementation on Risk of Fractures and Falls According to Dosage and Interval: A Meta-Analysis
Endocrinology and Metabolism
2022 .04
-
Effect of Vitamin K2 Alone or in Combination on Various Bone Turnover Markers Amongst Postmenopausal Females
대한골대사학회지
2021 .01
-
Efficacy and safety of vitamin D3 B.O.N intramuscular injection in Korean adults with vitamin D deficiency
Osteoporosis and Sarcopenia
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0