지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Since 2006, type 1 diabetes in Finland has plateaued and then decreased after the authorities’ decision to fortify dietary milk products with cholecalciferol. The role of vitamin D in innate and adaptive immunity is critical. A statistical error in the estimation of the recommended dietary allowance (RDA) for vitamin D was recently discovered; in a correct analysis of the data used by the Institute of Medicine, it was found that 8895 IU/d was needed for 97.5% of individuals to achieve values ≥50 nmol/L. Another study confirmed that 6201 IU/d was needed to achieve 75 nmol/L and 9122 IU/d was needed to reach 100 nmol/L. The largest meta-analysis ever conducted of studies published between 1966 and 2013 showed that 25-hydroxyvitamin D levels <75 nmol/L may be too low for safety and associated with higher all-cause mortality, demolishing the previously presumed U-shape curve of mortality associated with vitamin D levels. Since all-disease mortality is reduced to 1.0 with serum vitamin D levels ≥100 nmol/L, we call public health authorities to consider designating as the RDA at least three-fourths of the levels proposed by the Endocrine Society Expert Committee as safe upper tolerable daily intake doses. This could lead to a recommendation of 1000 IU for children <1 year on enriched formula and 1500 IU for breastfed children older than 6 months, 3000 IU for children >1 year of age, and around 8000 IU for young adults and thereafter. Actions are urgently needed to protect the global population from vitamin D deficiency.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Karvonen M / 1999 / The onset age of type 1 diabetes in Finnish children has become younger. The Finnish Childhood Diabetes Registry Group / Diabetes Care 22(7):1066~1070
Makinen M / 2014 / An increase in serum 25-hydroxyvitamin D concentrations preceded a plateau in type 1 diabetes incidence in Finnish children / J Clin Endocrinol Metab 99(11):E2353~E2356
van Halteren AG / 2002 / Redirection of human autoreactive T-cells upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3) / Diabetes 51(7):2119~2125
Hypponen E / 2001 / Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study / Lancet 358(9292):1500~1503
Papadimitriou DT / 2013 / Negativation of type 1 diabetes-associated autoantibodies to glutamic acid decarboxylase and insulin in children treated with oral calcitriol / J Diabetes 5(3):344~348
Makinen M / 2014 / An increase in serum 25-hydroxyvitamin D concentrations preceded a plateau in type 1 diabetes incidence in Finnish children / J Clin Endocrinol Metab 99(11):E2353~E2356
van Halteren AG / 2002 / Redirection of human autoreactive T-cells upon interaction with dendritic cells modulated by TX527, an analog of 1,25 dihydroxyvitamin D(3) / Diabetes 51(7):2119~2125
Hypponen E / 2001 / Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study / Lancet 358(9292):1500~1503
Papadimitriou DT / 2013 / Negativation of type 1 diabetes-associated autoantibodies to glutamic acid decarboxylase and insulin in children treated with oral calcitriol / J Diabetes 5(3):344~348
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