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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 661 - 671 (11page)
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Purpose: The purpose of this study is to explore the dynamic change of brainderived neurotrophic factor (BDNF) mRNA, protein, and tyrosine kinase-coupled receptor (TrkB) mRNA of the rat hippocampus under different stress conditions and to explore the influence of senescence on the productions expression.
Materials and Methods: By using forced-swimming in 4°C cold ice water and 25°C warm water, young and aged male rats were randomly divided into acute stress (AS) and chronic mild repeated stress (CMRS) subgroups, respectively.
BDNF productions and TrkB mRNA in the hippocampus were detected by using Western-blotting and reverse transcription-polymerase chain reaction (RT-PCR),separately, at 15, 30, 60, 180, and 720 min after the last stress session. Results: The short AS induced a significant increase in BDNF mRNA and protein in both age groups, but the changes in the young group were substantially greater than those of the aged group (p < 0.005). The CMRS resulted in a decrease in BDNF mRNA and protein, but a significant increase in TrkB mRNA in both young and age groups. The expression of BDNF mRNA and protein in the AS groups were higher than in the CMRS groups at 15, 30, and 60 min after stress. Conclusion: The results indicated that the up/down-regulation of BDNF and TrkB were affected by aging and the stimulus paradigm, which might reflect important mechanisms by which the hippocampus copes with stressful stimuli.
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참고문헌 (24)
참고문헌 신청
Adlard PA / 2004 / Voluntary exercise protects against stressinduced decreases in brain-derived neurotrophic factor protein expression / Neuroscience 124 : 985 ~ 992
Aggleton JP / 2000 / Identifying cortical inputs to the rat hippocampus that subserve allocentric spatial processes: a simple problem with a complex answer / Hippocampus 10 :
Beck KD / 1999 / Food deprivation modulates chronic stress effects on object recognition in male rats: role of monoamines and amino acids / Brain Res 830 : 56 ~ 71
Connor B / 1998 / The role of neuronal growth factors in neurodegenerative disorders of the human brain / Brain Res Rev 27 : 1 ~ 39
Croll SD / 1998 / Expression of BDNF and trkB as a function of age and cognitive performance / Brain Res 812 : 200 ~ 208
Aggleton JP / 2000 / Identifying cortical inputs to the rat hippocampus that subserve allocentric spatial processes: a simple problem with a complex answer / Hippocampus 10 :
Beck KD / 1999 / Food deprivation modulates chronic stress effects on object recognition in male rats: role of monoamines and amino acids / Brain Res 830 : 56 ~ 71
Connor B / 1998 / The role of neuronal growth factors in neurodegenerative disorders of the human brain / Brain Res Rev 27 : 1 ~ 39
Croll SD / 1998 / Expression of BDNF and trkB as a function of age and cognitive performance / Brain Res 812 : 200 ~ 208
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