지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.6
- 수록면
- 94 - 103 (10page)
이용수
초록· 키워드
오류제보하기
Korean red ginseng is known to have anti-stress and memory enhancing effects. Recent studies suggested that stress-induced inhibition of adult neurogenesis in hippocampus may contribute. in part. to decreased negative feedback inhibition of HPA axis. In order to elucidate the mechanism of Korean red ginseng in anti-stress and memory enhancing effects. we observed the effects of repeated treatment of Korean red ginseng total saponin (GTS. 50 mg/kg. i.p.) in response to repeated unpredictable stress for 10 days. Male Sprague-Dawley rats (230 - 260 g) received with either GTS (50 mg/kg. i.p.) or vehicle (I ml/kg. i.p.) I h before stress for 10 days. Rats were injected with bromodeoxyuridine (BrdU. 50 mg/kg. i.p.) 16-18 hr after last stress procedure. and were sacrificed 2 hr later by perfusion. Immunohistochemistry of BrdU was done to measure proliferation of neural progenitor cells in hippocampus. which was used as an index of neurogenesis. Repeated GTS treatment for [0 days increased neurogenesis in subgranular zone area of dentate gyrus (SGZ). but not hilus. compared with vehicle-treated rats. Repeated unpredictable stress did not affect the neurogenesis compared with controls. while repeated GTS treatment increased neurogenesis in SGZ in repeated unpredictable stress-exposed group. BDNF mRNA was also measured in subregions of hippocampus by in situ hybridization. BDNF mRNA expression in CA3 and CA I pyramidal cell layer was increased by repeated GTS treatment but not in dentate granule cell layer. Repeated unpredictable stresses significantly decreased BDNF mRNA expression in all subregions of hippocampus. but repeated GTS treatment did not prevent stress-induced BDNF mRNA downregulation. Given that repeated GTS treatment increased proliferation of neural progenitor cells in repeated unpredictable stress-exposed rats in the presence of decreased BDNF mRNA expression in dentate granule cell layer. it raise the possibility that BDNF may not playa significant role in GTS-mediated increase of neurogenesis in adult rat hippocampus. Also. these results suggest that repeated GTS treatment increased neurogenesis of SGZ and BDNF mRNA expression. which may account for memory enhancing effect of Korean red ginseng. In addition. repeated GTS treatment appears not to have anti-stress effects in terms of neurotrophin. but GTS-mediated increase of neurogenesis in hippocampus may contribute to increase negative feedback inhibition of HPA axis.
목차
Abstract
서론
재료 및 방법
결과
고찰
요약
감사의 말씀
인용문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Acute Stress and Chronic Stress Change Brain-Derived Neurotrophic Factor (BDNF) and Tyrosine Kinase- Coupled Receptor (TrkB) Expression in Both Young and Aged Rat Hippocampus
Yonsei Medical Journal
2010 .01
-
우울증에서 Brain - Derived Neurotrophic Factor의 역할
생물치료정신의학
2005 .12
-
Effect of acupuncture on memory function in old rats
대한한의학회지
2017 .06
-
Epigenetic Regulation of BDNF Gene in Response to Stress
PSYCHIATRY INVESTIGATION
2010 .01
-
Brain-Derived Neurotrophic Factor와 알쯔하이머병
생물치료정신의학
2005 .12
-
우울증 환자의 혈액에서 측정되는 BDNF 농도 변화와 그 의미
신경정신의학
2009 .01
-
Influence of Prenatal Noise and Music on the Spatial Memory and Neurogenesis in the Hippocampus of Developing Rats
스트레스硏究
2005 .11
-
Various Types of Stress Deteriorate Spatial Memory through Inhibition of Cell Proliferation in the Hippocampus of Rats
스트레스硏究
2011 .09
-
NOX4 affects the stage of neural differentiation in the hippocampus through independent with an inflammatory contribution
한국실험동물학회 학술발표대회 논문집
2020 .02
-
The Roles of BDNF in the Pathophysiology of Major Depression and in Antidepressant Treatment
PSYCHIATRY INVESTIGATION
2010 .01
-
A Review of Brain-derived Neurotrophic Factor as a Candidate Biomarker in Schizophrenia
Clinical Psychopharmacology and Neuroscience
2012 .01
-
Effects of Prenatal Cnidium officinale Makino Treatment on Spatial Memory and Neurogenesis in the Hippocampus of Rat Pups Born from Maternal Rats Exposed to Noise Stress during Pregnancy
대한한의학회지
2006 .12
-
감각 자극과 치료적 환경이 외상성 뇌손상 흰쥐의 BDNF 발현에 미치는 영향
대한고유수용성신경근촉진법학회지
2007 .01
-
Impact of Several Types of Stresses on Short-term Memory and Apoptosis in the Hippocampus of Rats
International Neurourology Journal
2013 .01
-
정신분열병 환자의 혈청에서 Brain-Derived Neurotrophic Factor 증가
생물정신의학
2004 .01
-
트레드밀 운동이 당뇨유발 흰쥐의 기억력 장애에 미치는 영향
스트레스硏究
2011 .06
-
Reversion of BDNF, Akt and CREB in Hippocampus of Chronic Unpredictable Stress Induced Rats: Effects of Phytochemical, Bacopa Monnieri
PSYCHIATRY INVESTIGATION
2017 .01
-
우울증의 새로운 신경생물학
생물정신의학
2001 .01
-
Effects of swimming on functional recovery and brain-derived neurotrophic factor (BDNF) mRNA expression after sciatic crushed nerve injury in rats
대한물리치료학회지(JKPT)
2004 .01
-
Chronic Administration of Bacopa Monniera Increases BDNF Protein and mRNA Expressions: A Study in Chronic Unpredictable Stress Induced Animal Model of Depression
PSYCHIATRY INVESTIGATION
2014 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
고지방 식이 섭취로 유발된 비만 쥐의 시상하부 BDNF발현과 렙틴 mRNA 발현, 혈청 렙틴과 항비만과의 관계에 대한 운동트레이닝의 효과
우상헌
,
강성훈
,
우진희
외 1명
한국식품영양과학회지
2013
.10
운동유형이 노인 여성의 체력과 BDNF, IGF-1, Cortisol에 미치는 영향
안용덕
,
박상용
한국체육과학회지
2013
.08
Effects of Acute Soccer Game on Serum Levels of Neurotrophins and Neurocognitive Functions in Male Adolescents
Jung-Su Yang
,
Shin-Hwan Yoo
,
Su-Youn Cho
외 1명
생명과학회지
2012
.11
아침 유산소운동에 따른 중학생의 BDNF와 작업기억력 변화에 대한 연구
최재일
,
김재호
,
전용균
외 1명
한국체육과학회지
2012
.08
참당귀 에탄올 추출물의 Scopolamin 투여 마우스의 인지능력 개선에 미치는 영향
장순애
,
이명섭
,
김미경
외 2명
동아시아식생활학회 학술발표대회논문집
2010
.11
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2009-524-014099610