지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 453 - 468 (16page)
이용수
초록· 키워드
오류제보하기
There is a conserved ATPase domain in topoisomerase II (topo II) and heat shock protein 90 (Hsp90) which belong to the GHKL (gyrase, Hsp90, histidine kinase, and MutL) family. The inhibitors that target each of topo II and Hsp90 are intensively studied as anti-cancer drugs since they play very important roles in cell proliferation and survival. Therefore the development of dual targeting anti-cancer drugs for topo II and Hsp90 is suggested to be a promising area. The topo II and Hsp90 inhibitors, known to bind to their ATP binding site, were searched. All the inhibitors investigated were docked to both topo II and Hsp90. Four candidate compounds as possible dual inhibitors were selected by analyzing the molecular docking study. The pharmacophore model of dual inhibitors for topo II and Hsp90 were generated and the design of novel dual inhibitor was proposed.
목차
등록된 정보가 없습니다.
참고문헌 (54)
참고문헌 신청
Agatsuma, T / 2002 / Halohydrin and oxime derivatives of radicicol: Synthesis and antitumor activities / Bioorg. Med. Chem 10:3445~3454
Barker, C. R / 2006 / The topoisomerase II-Hsp90 complex: A new chemotherapeutic target? / Int. J. Cancer 118:2685~2693
Basarab, G. S / 2015 / Responding to the challenge of untreatable gonorrhea: ETX0914, a first-inclass agent with a distinct mechanism-of-action against bacterial Type II topoisomerases / Sci. Rep 5:11827
Baviskar, A. T / 2011 / N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIαand induce apoptosis in G1/S phase / J. Med. Chem 54:5013~5030
Brough, P. A / 2008 / 4,5-diarylisoxazole Hsp90chaperone inhibitors: Potential therapeutic agents for the treatment of cancer / J. Med. Chem 51:196~218
Barker, C. R / 2006 / The topoisomerase II-Hsp90 complex: A new chemotherapeutic target? / Int. J. Cancer 118:2685~2693
Basarab, G. S / 2015 / Responding to the challenge of untreatable gonorrhea: ETX0914, a first-inclass agent with a distinct mechanism-of-action against bacterial Type II topoisomerases / Sci. Rep 5:11827
Baviskar, A. T / 2011 / N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIαand induce apoptosis in G1/S phase / J. Med. Chem 54:5013~5030
Brough, P. A / 2008 / 4,5-diarylisoxazole Hsp90chaperone inhibitors: Potential therapeutic agents for the treatment of cancer / J. Med. Chem 51:196~218
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Heat Shock Protein 90 (HSP90) and Immune Regulation
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .03
-
Traditional and Novel Mechanisms of Heat Shock Protein 90 (HSP90) Inhibition in Cancer Chemotherapy Including HSP90 Cleavage
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
-
Studies on the Mechanism of HSP90 Inhibitors in Colorectal Cancer
대한외과학회 학술대회 초록집
2018 .11
-
Small Molecule Inhibitors toDisrupt Protein-protein Interactions of Heat Shock Protein 90 Chaperone Machinery
대한암예방학회지
2015 .01
-
Heat Shock Protein Association with Clinico-Pathological Characteristics of Gastric Cancer in Jordan : HSP70 is Predictive of Poor Prognosis
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Transcriptional responses of heat shock protein 90 (HSP90) and heat shock protein 83 (HSP83) genes by salinity changes in the intertidal crab Macrophthalmus japonicus
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
The Prognostic Impact of Heat Shock Proteins Expression in Patients with Esophageal Cancer: A Meta-Analysis
Yonsei Medical Journal
2015 .01
-
Synergistic induction of anticancer activity by a novel HSP90 inhibitor NXD30020 combined therapy with chemotherapy through an apoptotic process in Her2 positive gastric cancer
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Apoptosis in response to heat stress is positively associated with heat-shock protein 90 expression in chicken myocardial cells
Journal of Veterinary Science
2017 .06
-
Thermal Injury Induces Small Heat Shock Protein in the Optic Nerve Head In Vivo
Korean Journal of Ophthalmology
2021 .12
-
2',4'-Dimethoxychalcone 유도체 합성 및 비소폐암세포주에서 항암 활성평가
약학회지
2016 .01
-
Differential Expression of HSP90𝛽 in MDA-MB-231 and MCF-7 Cell Lines after Treatment with Doxorubicin
Journal of Pharmacopuncture
2019 .01
-
Expression levels of heat shock protein 27 and cellular FLICE-like inhibitory protein in prostate cancer correlate with Gleason score sum and pathologic stage
Investigative and Clinical Urology
2015 .01
-
The association of Hsp90 expression induced by aspirin with anti-stress damage in chicken myocardial cells
Journal of Veterinary Science
2016 .03
-
Serial Changes of Heat Shock Protein 70 and Interleukin-8 in Burn Blister Fluid
Annals of Dermatology
2017 .01
-
Ten-year Nationwide Population-based Survey on the Characteristics of Children with Henoch-Schӧnlein Purpura in Korea
Journal of Korean Medical Science
2018 .01
-
The Different Expression Patterns of HSP22, a Late Embryogenesis Abundant-like Protein, in Hypertrophic H9C2 Cells Induced by NaCl and Angiotensin II
Electrolytes & Blood Pressure
2018 .01
-
Mornitoring and Identification of Human Astrovirus from Groundwater in Korea Based on Highly Sensitive RT-nested PCR Primer Sets
대한의생명과학회지
2021 .12
-
Potential Prognostic Value of Histone Deacetylase 6 and Acetylated Heat-Shock Protein 90 in Early-Stage Breast Cancer
Journal of Breast Cancer
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0