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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 대한치매학회 Dementia and Neurocognitive Disorders(대한치매학회지) Dementia and Neurocognitive Disorders(대한치매학회지) 제17권 제4호
- 발행연도
- 2018.1
- 수록면
- 163 - 173 (11page)
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Background and Purpose: Behavioral variant frontotemporal dementia (bvFTD) is a subtype of frontotemporal dementia, which has clinical symptoms of progressive personality and behavioral changes with deterioration of social cognition and executive functions. The pathology of bvFTD is known to be tauopathy or TDP-43 equally. We analyzed the 18F-THK5351 positron emission tomography (PET) scans, which were recently developed tau PET, in patients with clinically-diagnosed bvFTD. Methods: Forty-eight participants, including participants with behavioral variant frontotemporal dementia (bvFTD, n =3), Alzheimer's disease (AD, n =21) and normal cognition (NC, n =24) who completed 3T magnetic resonance images, 18F-THK5351 PET scans, and detailed neuropsychological tests were included in the study. Voxel-wise statistical analysis and region of interest (ROI)-based analyses were performed to evaluate the retention of THK in bvFTD patients. Results: In the voxel-based and ROI-based analyses, patients with bvFTD showed greater THK retention in the prefrontal, medial frontal, orbitofrontal, anterior cingulate, insula, anterior inferior temporal and striatum regions compared to NC participants. Left-right asymmetry was noted in the bvFTD patients. A patient with extrapyramidal symptoms showed much greater THK retention in the brainstem. Conclusions: The distribution of THK retention in the bvFTD patients was mainly in the frontal, insula, anterior temporal, and striatum regions which are known to be the brain regions corresponding to the clinical symptoms of bvFTD. Our study suggests that 18F-THK5351 PET imaging could be a supportive tool for diagnosis of bvFTD.
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참고문헌 (32)
참고문헌 신청
Mackenzie IR / 2010 / Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update / Acta Neuropathol 119:1~4
Mackenzie IR / 2008 / Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions / Brain 131:1282~1293
Kertesz A / 2005 / The evolution and pathology of frontotemporal dementia / Brain 128:1996~2005
Rascovsky K / 2013 / Can clinical features predict tau pathology in patients with behavioral variant frontotemporal dementia (bvFTD)? / Neurology 80:P05.101
Chare L / 2014 / New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications / J Neurol Neurosurg Psychiatry 85:865~870
Mackenzie IR / 2008 / Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions / Brain 131:1282~1293
Kertesz A / 2005 / The evolution and pathology of frontotemporal dementia / Brain 128:1996~2005
Rascovsky K / 2013 / Can clinical features predict tau pathology in patients with behavioral variant frontotemporal dementia (bvFTD)? / Neurology 80:P05.101
Chare L / 2014 / New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications / J Neurol Neurosurg Psychiatry 85:865~870
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