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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 145 - 156 (12page)
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초록· 키워드
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Neonatal hypoxic-ischemic encephalopathy (HIE) is an ongoing process, which may persist for weeks to years after an acute asphyxial insult, causing delayed programmed cell death. The typical clinical signs and the pathological findings of HIE manifest as the condition evolves in a step-wise manner, beginning with an acute phase, followed by a latent, a secondary energy failure phase, and eventually a tertiary brain injury phase. To date, therapeutic hypothermia (TH) is the only effective treatment strategy known to improve mortality and prevent neurodevelopmental disabilities, as has been proven by the results of several randomized controlled clinical trials. The current protocols describing the use of TH for newborns of gestational age ≥36 weeks with HIE, associated with clinical evidence of asphyxia along with neurological signs of moderate- to-severe encephalopathy, observed at ≤6 hours of age, are close to optimal. Most comorbid conditions observed during TH are related to asphyxia. TH is a safe treatment option—benign sinus bradycardia and thrombocytopenia are frequent hypothermia-related complications. Additional adjuvant agents, which may augment hypothermic neuroprotection are being investigated, and a few of them, such as erythropoietin and melatonin appear to be promising agents for use in this condition. Establishing our own nationwide cooling systems and guidelines for a standard treatment protocol to manage HIE are warranted in the future.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Azzopardi D / 2014 / Effects of hypothermia for perinatal asphyxia on childhood outcomes / N Engl J Med 371 : 140 ~ 149
Azzopardi DV / 2009 / Moderate hypothermia to treat perinatal asphyxial encephalopathy / N Engl J Med 361 : 1349 ~ 1358
Drury PP / 2014 / Mechanisms of hypothermic neuroprotection / Clin Perinatol 41 : 161 ~ 175
Edwards AD / 2010 / Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial
Fleiss B / 2012 / Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy? / Lancet Neurol 11 : 556 ~ 566
Azzopardi DV / 2009 / Moderate hypothermia to treat perinatal asphyxial encephalopathy / N Engl J Med 361 : 1349 ~ 1358
Drury PP / 2014 / Mechanisms of hypothermic neuroprotection / Clin Perinatol 41 : 161 ~ 175
Edwards AD / 2010 / Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial
Fleiss B / 2012 / Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy? / Lancet Neurol 11 : 556 ~ 566
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