지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Background: To assess the cost-effectiveness of drug therapy to prevent osteoporotic fractures in postmenopausal women with osteopenia in Korea. Methods: A Markov cohort simulation was conducted for lifetime with a hypothetical cohort of postmenopausal women with osteopenia and without prior fractures. They were assumed to receive calcium/vitamin D supplements only or drug therapy (i.e., raloxifene or risedronate) along with calcium/vitamin D for 5 years. The Markov model includes fracture-specific and non-fracture specific health states (i.e. breast cancer and venous thromboembolism), and all-cause death. Published literature was used to determine the model parameters. Local data were used to estimate the baseline incidence rates of fracture in those with osteopenia and the costs associated with each health state. Results: From a societal perspective, the estimated incremental cost-effectiveness ratios (ICERs) for the base cases that had T-scores between -2.0 and -2.4 and began drug therapy at the age of 55, 60, or 65 years were $16,472, $6,741, and -$13,982 per quality-adjusted life year (QALY) gained, respectively. Sensitivity analyses for medication compliance, risk of death following vertebral fracture, and relaxing definition of osteopenia resulted in ICERs reached to $24,227 per QALY gained. Conclusions: ICERs for the base case and sensitivity analyses remained within the World Health Organization’s willingness-to-pay threshold, which is less than per-capita gross domestic product in Korea (about $25,700). Thus, we conclude that drug therapy for osteopenia would be a cost-effective intervention, and we recommend that the Korean National Health Insurance expand its coverage to include drug therapy for osteopenia.
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참고문헌 (40)
참고문헌 신청
World Health Organization / Prevention and management of osteoporosis
Looker AC / 1997 / Prevalence of low femoral bone density in older U.S. adults from NHANES III / J Bone Miner Res 12:1761~1768
National Evidence-based Healthcare Collaborating Agency / 2011 / Developing Korea-specific assessment criteria for osteoporosis / National Evidence-based Healthcare Collaborating Agency
Siris ES / 2008 / Effects of risedronate on fracture risk in postmenopausal women with osteopenia / Osteoporos Int 19:681~686
Siris ES / 2001 / Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women : results from the National Osteoporosis Risk Assessment / JAMA 286:2815~2822
Looker AC / 1997 / Prevalence of low femoral bone density in older U.S. adults from NHANES III / J Bone Miner Res 12:1761~1768
National Evidence-based Healthcare Collaborating Agency / 2011 / Developing Korea-specific assessment criteria for osteoporosis / National Evidence-based Healthcare Collaborating Agency
Siris ES / 2008 / Effects of risedronate on fracture risk in postmenopausal women with osteopenia / Osteoporos Int 19:681~686
Siris ES / 2001 / Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women : results from the National Osteoporosis Risk Assessment / JAMA 286:2815~2822
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