지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background: The effects of subclinical hyperthyroidism on fracture risk induced by thyroid-stimulating hormone (TSH) suppression therapy in patients with thyroid cancer still remains controversial. We performed a meta-analysis and systematic review to evaluate the effects of TSH suppression therapy on osteoporotic fracture in patients with thyroid cancer. Methods: We performed a systematic search to identify studies which included osteoporotic fractures (hip fracture and vertebral fracture) in patients on TSH suppression therapy for thyroid cancer. Main outcome measures were occurrence and risk of osteoporotic fractures including hip and vertebral fractures between patients and controls. Results: A systematic search yielded a total of 8 studies appropriate for review which included osteoporotic fracture outcome in patients on TSH suppression therapy for thyroid cancer. Studies with larger number of subjects showed the higher risk of osteoporotic fracture in group with TSH suppression therapy, although studies with smaller sample size presented a similar risk of fracture with control group. Conclusions: Although studies were limited by small numbers, results suggested possible association between chronic TSH suppression therapy and the increased risk of osteoporotic fractures in patients with thyroid cancer.
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참고문헌 (24)
참고문헌 신청
Williams GR / 2018 / Thyroid diseases and bone health / J Endocrinol Invest 41:99~109
Tuchendler D / 2014 / The influence of thyroid dysfunction on bone metabolism / Thyroid Res 7:12
Williams GR / 2009 / Actions of thyroid hormones in bone / Endokrynol Pol 60:380~388
Haugen BR / 2016 / 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer / Thyroid 26:1~133
Rosario PW / 2016 / Symptoms of thyrotoxicosis, bone metabolism and occult atrial fibrillation in older women with mild endogenous subclinical hyperthyroidism / Clin Endocrinol (Oxf) 85:132~136
Tuchendler D / 2014 / The influence of thyroid dysfunction on bone metabolism / Thyroid Res 7:12
Williams GR / 2009 / Actions of thyroid hormones in bone / Endokrynol Pol 60:380~388
Haugen BR / 2016 / 2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer / Thyroid 26:1~133
Rosario PW / 2016 / Symptoms of thyrotoxicosis, bone metabolism and occult atrial fibrillation in older women with mild endogenous subclinical hyperthyroidism / Clin Endocrinol (Oxf) 85:132~136
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