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논문 기본 정보

자료유형
학술저널
저자정보
Kim Kyoung Jin (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University College o) Choi Jimi (Department of Biostatistics Korea University College of Medicine Seoul Korea.) Kim Ji Yoon (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University College o) Bae Jae Hyun (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University College o) Kim Kyeong Jin (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University College o) Kim Hee Young (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University College o) Yoo Hye Jin (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University College o) Seo Ji A (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University College o) Kim Nan Hee (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University College o) Choi Kyung Mook (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University College o) Baik Sei Hyun (Division of Endocrinology and Metabolism Department of Internal Medicine Korea University College o) 김신곤 (고려대학교) 김남훈 (고려대학교)
저널정보
한국지질동맥경화학회(구 한국지질학회) 지질·동맥경화학회지 지질·동맥경화학회지 제10권 제3호
발행연도
2021.9
수록면
322 - 333 (12page)
DOI
10.12997/jla.2021.10.3.322

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Objective: We aimed to investigate the association between statin use and the risk of major osteoporotic fractures in patients with metabolic syndrome (MetS). Methods: A nested case-control study was performed in patients with MetS (≥50 years) who had no history of osteoporotic fracture using the Korean National Health Insurance Service- Health Screening Cohort. This study included 17,041 patients diagnosed with new-onset osteoporotic fractures and controls matched in a 1:1 ratio by age, sex, body mass index, cohort entry date, and follow-up duration. Conditional logistic regression analysis was used to evaluate covariate-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results: During a 4-year follow-up period, the risk of major osteoporotic fractures was significantly reduced by 9% (OR, 0.91; 95% CI, 0.85?0.97) in statin users compared with that in non-users. Among subtypes of major osteoporotic fracture, a risk reduction with statin therapy was significant for vertebral fracture (OR, 0.86; 95% CI, 0.79?0.94) but not for non-vertebral fracture (OR, 0.97; 95% CI, 0.88?1.06). Longer duration (OR, 0.97; 95% CI, 0.96?0.99, per 1-year increase) and higher cumulative dose (OR, 0.97; 95% CI, 0.95?0.99, per 365 defined daily doses) of statins were negatively associated with the risk of major osteoporotic fracture. Conclusion: This study supports the hypothesis that statin therapy has a beneficial effect on major osteoporotic fractures, especially vertebral fractures, in patients with MetS.
#HMG-CoA reductase inhibitor #Statin #Osteoporotic fractures #Metabolic syndrome #Case-control studies

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참고문헌 (64)

참고문헌 신청
Nguyen P / 2008 / Liver lipid metabolism / J Anim Physiol Anim Nutr(Berl) 92:272~283 google schola Cahill GF Jr / 2006 / Fuel metabolism in starvation / Annu Rev Nutr 26:1~22 google schola Hashimoto T / 2000 / Defect in peroxisome proliferator-activated receptor α-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting / J Biol Chem 275:28918~28928 google schola Guan HP / 2009 / Accelerated fatty acid oxidation in muscle averts fastinginduced hepatic steatosis in SJL/J mice / J Biol Chem 284:24644~24652 google schola Chitraju C / 2012 / Lipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress / J Lipid Res 53:2141~2152 google schola

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