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- 자료유형
- 학술저널
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- 2017.1
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This study investigates the therapeutic effect of a nanocurcumin formulation (NCF) containing nanocurcumin (NC) and pyrroloquinoline quinone (PQQ) on ameliorating hypoxia-induced stress in hypertrophied primary human ventricular cardiomyocytes (HVCM) under hypoxic conditions, as validated in a Sprague-Dawley rat model of chronic hypobaric hypoxia (cHH)-induced right ventricular hypertrophy (RVH). Based on our previous findings, here, we analyzed the improvement in the protective efficacy of NCF against mitochondrial damage. The electron transport chain Complexes’ activities were analyzed as a chief operational center for mitochondrial homeostasis, along with key gene and protein markers for mitochondrial biogenesis, redox function, fatty acid oxidation, bio-energetic deficit and cell survival. NCF supplementation imparts cyto-protection from hypoxia-induced hypertrophy and damage in both in vitro and in vivo models while maintaining mitochondrial homeostasis better than NC and PQQ alone. This study proposes the use of NCF as a potential candidate molecule for imparting protection from high altitude-induced maladies in ascendants.
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참고문헌 (23)
참고문헌 신청
Beg AA / 1996 / An essential role for NF-kappaB in preventing TNF-alpha-induced cell death / Science 274 : 782 ~ 784
Choksi KB / 2004 / Oxidatively damaged proteins of heart mitochondrial electron transport complexes / Biochim Biophys Acta 1688 : 95 ~ 101
Essop MF / 2007 / Cardiac metabolic adaptations in response to chronic hypoxia / J Physiol 584 : 715 ~ 726
Fritah A / 2010 / Elevated expression of the metabolic regulator receptor-interacting protein 140results in cardiac hypertrophy and impaired cardiac function / Cardiovasc Re
Gordon JW / 2011 / Multiple facets of NF-κB in the heart : to be or not to NF-κB / Circ Res 108 : 1122 ~ 1132
Choksi KB / 2004 / Oxidatively damaged proteins of heart mitochondrial electron transport complexes / Biochim Biophys Acta 1688 : 95 ~ 101
Essop MF / 2007 / Cardiac metabolic adaptations in response to chronic hypoxia / J Physiol 584 : 715 ~ 726
Fritah A / 2010 / Elevated expression of the metabolic regulator receptor-interacting protein 140results in cardiac hypertrophy and impaired cardiac function / Cardiovasc Re
Gordon JW / 2011 / Multiple facets of NF-κB in the heart : to be or not to NF-κB / Circ Res 108 : 1122 ~ 1132
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