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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 372 - 379 (8page)
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초록· 키워드
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Interleukin (IL)-4 inhibits proliferation of several
human cancer cell lines in vitro. Although IL-4
is known to regulate proliferation of lymphocytes
by modulating p27KIP1 expression, the
mechanism involved in the IL-4-induced growth
inhibition of nonhematopoietic cancer cells has
not been fully elucidated. Previously, w e reported
that IL-4 suppressed proliferation of
human renal cell carcinoma (RCC) cell lines in
vitro. Here, we show that IL-4 inhibits cell cycle
progression at the G1 phase in Caki-1 cells by
increasing the expression of p21WAF1 and interferon
regulatory factor (IRF)-1, and decreasing
the cyclin dependent kinase (CDK) 2 activity.
Up-regulation of p21WAF1 and IRF-1 expression is
transcriptional, but independent of p53. The
levels of p21WAF1 and IRF-1 proteins were enhanced
as early as 1 h after IL-4 treatment.
CDK2 activity started to decline at 4 h after IL-4
treatment, and by 24 h, was ∼50% of the control.
Neither the protein expressions of p27KIP1
and p16INK4a, nor the phosphorylation level of
pRb was changed. The importance of p21WAF1
and IRF-1 in the growth inhibition induced by
IL-4 was confirmed by antisense oligonucleotide
transfection. Both of p21WAF1 and IRF-1 antisense
oligonucleotides prevented IL-4-mediated growth
inhibition by ∼30% compared to the respective
sense oligonucleotides. In summary, our study
indicated that p21WAF1 and IRF-1 mediate the
growth inhibitory effect of IL-4 in human RCC
cells.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
/ / Cellular commitment to oncogene-induced transformationor apoptosis is dependent on the transcription factor IRF-1 : 829 ~ 39
/ / Murine interleukin-4displays potent anti-tumor activity in vivo : 503 ~ 12
/ / Single-step method of RNAisolation by acid guanidinium thiocyanate-phenol-chloroformextraction : 156 ~ 9
/ 1995 / Transforming growth factor beta induces the cyclin-dependentkinase inhibitor p21 through a p53-independentmechanism : 5545 ~ 9
/ 1995 / but aredefective in G1 checkpoint control : 675 ~ 84
/ / Murine interleukin-4displays potent anti-tumor activity in vivo : 503 ~ 12
/ / Single-step method of RNAisolation by acid guanidinium thiocyanate-phenol-chloroformextraction : 156 ~ 9
/ 1995 / Transforming growth factor beta induces the cyclin-dependentkinase inhibitor p21 through a p53-independentmechanism : 5545 ~ 9
/ 1995 / but aredefective in G1 checkpoint control : 675 ~ 84
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