지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 204 - 210 (7page)
이용수
초록· 키워드
오류제보하기
Mamalian epithelia produce the various anti-microbial peptides against the bacterial or viral infection, thereby acting as the active imune modulators in the innate immunity. In this study, we examined the efects of the various proin-flamatory cytokines or LPS on cell viability and antimicrobial β-defensin gene expressions in human corneal epithelial cels. Results showed that the cytokines or LPS did not exert severe cytotoxic effects on the cells, and that β-de-fensin 1 was constitutively expressed, while β- defensin 2 was specifically induced by IL-1β, supporting the idea that these cytokines or LPS involve the defense mechanism in the cornea. Furthermore, the reporter and gel shift asay to define the induction mechanism of β-defensin 2 by IL-1β demonstrated that the most proximal NF-κB site on the promoter region of β-defensin 2 was not critical for the process. Data obtained ocular diseases showed that our in vitro results were relevant in the clinical settings. Our results clearly demonstrated that β-defensin 1 and 2 are important antimicrobial peptides in the corneal tisues, and that the mechanistic induction proces of β-defensin 2 by IL-1β is not solely dependent on proximal NF-κB site activation, thus suggesting that the long distal portion of the promoter is neded for the ful respon-siveness toward IL-1β.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
/ 1996 / Tran-scriptional regulation of human inducible nitric oxide synthase gene by cytokines Initial analysis of the human NOS2 promoter (s2) : 1054 ~ 9
/ 1998 / A peptide antibiotic from human skin
/ 1998 / Analysis of the cytokine-stimulated human inducible nitric oxide synthase Characterization of diferences between human and mouse iNOS promoters i (s) : 871 ~ 8
/ 1998 / Multiple NF-κB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene : 15148 ~ 56
/ 1999 / A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated α-defensins : 420 ~ 1
/ 1998 / A peptide antibiotic from human skin
/ 1998 / Analysis of the cytokine-stimulated human inducible nitric oxide synthase Characterization of diferences between human and mouse iNOS promoters i (s) : 871 ~ 8
/ 1998 / Multiple NF-κB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene : 15148 ~ 56
/ 1999 / A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated α-defensins : 420 ~ 1
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Expression of Human β-defensin 2 mRNA by Lipopolysaccharide in Human Corneal Epithelial Cells
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2004 .03
-
Saccharomyces cerevisiae에서 발현한 곤충 항균펩티드, defensin의 정제 및 특성 조사
생명과학회지
2002 .08
-
효모에서 활성형의 곤충유래 항균펩티드 defensin의 발현
생명과학회지
2002 .08
-
Active Defensin Derived from Insect Is Efficiently Secreted by Glucoamylase Signal Sequence in Yeast
한국동물학회 학술대회
1998 .01
-
Peptide Consisting of C-Terminal 15 Amino Acids of Human β-Defensin-3 Inhibits Aggregatibacter actinomycetemcomitans Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption
한국미생물학회 학술대회논문집
2015 .04
-
Molecular Cloning of the Defensin Homologue Gene from the Firefly , Pyrocoelia rufa
한국생명과학회 학술발표회
2001 .01
-
Characterization and cDNA Cloning of a Defensin-Like Peptide, Harmoniasin, from Harmonia axyridis
Journal of Microbiology and Biotechnology
2012 .01
-
Molecular Cloning of a cDNA Encoding the Defensin of a Novel Family Member from the Firefly, Pyrocoelia rufa
한국응용곤충학회 학술발표회
2001 .01
-
Interleukin-32γ Transgenic Mice Resist LPS-Mediated Septic Shock
Journal of Microbiology and Biotechnology
2014 .01
-
Sestrin2 inhibits YAP activation and negatively regulates corneal epithelial cell proliferation
Experimental and Molecular Medicine
2020 .01
-
Synergistic Effect of Interleukin-18 on the Expression of Lipopolysaccharide- Induced IP-10 (CXCL-10) mRNA in Mouse Peritoneal Macrophages
Journal of Microbiology and Biotechnology
2006 .01
-
Interleukin-10 endogenously expressed in microglia preventslipopolysaccharide-induced neurodegeneration in the ratcerebral cortex in vivo
Experimental and Molecular Medicine
2007 .01
-
Association of an Anti-inflammatory Cytokine Gene IL4 Polymorphism with the Risk of Type 2 Diabetes Mellitus in Korean Populations
Genomics & informatics
2011 .01
-
The Effect of Quercetin in Corneal Opacity Induced by Mitomycin-C
한국현미경학회지
2014 .01
-
키토산이 Th1과 Th2 사이토카인 생성에 미치는 효과
생명과학회지
2009 .03
-
LPS Sensing Mechanism of Human Astrocytes : Evidence of Functional TLR4 Expression and Requirement of Soluble CD14
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2017 .12
-
In vivo action of IL-27: reciprocal regulation of Th17 and Treg cells in collagen-induced arthritis
Experimental and Molecular Medicine
2013 .01
-
발효 꾸지뽕(Cudrania tricuspidata) 열매 추출물이 마우스 비장세포의 cytokine 생성에 미치는 영향
생명과학회지
2013 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0