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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 10 (10page)
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The etiology of disease pathogenesis can be largely explained by genetic variations and several types of environmental factors. In genetically disease-susceptible individuals, subsequent environmental triggers may induce disease development. The human body is colonized by complex commensal microbes that have co-evolved with the host immune system. With the adaptation to modern lifestyles, its composition has changed depending on host genetics, changes in diet, overuse of antibiotics against infection and elimination of natural enemies through the strengthening of sanitation. In particular, commensal microbiota is necessary in the development, induction and function of T cells to maintain host immune homeostasis. Alterations in the compositional diversity and abundance levels of microbiota, known as dysbiosis, can trigger several types of autoimmune and inflammatory diseases through the imbalance of T-cell subpopulations, such as Th1, Th2, Th17 and Treg cells. Recently, emerging evidence has identified that dysbiosis is involved in the progression of rheumatoid arthritis, type 1 and 2 diabetic mellitus, and asthma, together with dysregulated T-cell subpopulations. In this review, we will focus on understanding the complicated microbiota-T-cell axis between homeostatic and pathogenic conditions and elucidate important insights for the development of novel targets for disease therapy.
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참고문헌 (29)
참고문헌 신청
Atarashi K / 2011 / Induction of colonic regulatory T cells by indigenous Clostridium species / Science 331 : 337 ~ 341
Belkaid Y / 2014 / Role of the microbiota in immunity and inflammation / Cell 157 : 121 ~ 141
Gaboriau-Routhiau V / 2009 / The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses / Immunity 31 : 677 ~ 689
Gaffen SL / 2009 / The role of interleukin-17 in the pathogenesis of rheumatoid arthritis / Curr Rheumatol Rep 11 : 365 ~ 370
Harrington LE / 2005 / Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages / Nat Immunol 6 : 1123 ~ 1132
Belkaid Y / 2014 / Role of the microbiota in immunity and inflammation / Cell 157 : 121 ~ 141
Gaboriau-Routhiau V / 2009 / The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses / Immunity 31 : 677 ~ 689
Gaffen SL / 2009 / The role of interleukin-17 in the pathogenesis of rheumatoid arthritis / Curr Rheumatol Rep 11 : 365 ~ 370
Harrington LE / 2005 / Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages / Nat Immunol 6 : 1123 ~ 1132
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