지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1 - 10 (10page)
이용수
초록· 키워드
오류제보하기
Replication-independent incorporation of variant histone H3.3 has a profound impact on chromatin function and numerous cellular processes, including the differentiation of muscle cells. The histone chaperone HIRA and H3.3 have essential roles in MyoD regulation during myoblast differentiation. However, the precise mechanism that determines the onset of H3.3 deposition in response to differentiation signals is unclear. Here we show that HIRA is phosphorylated by Akt kinase, an important signaling modulator in muscle cells. By generating a phosphospecific antibody, we found that a significant amount of HIRA was phosphorylated in myoblasts. The phosphorylation level of HIRA and the occupancy of phosphorylated protein on muscle genes gradually decreased during cellular differentiation. Remarkably, the forced expression of the phosphomimic form of HIRA resulted in reduced H3.3 deposition and suppressed the activation of muscle genes in myotubes. Our data show that HIRA phosphorylation limits the expression of myogenic genes, while the dephosphorylation of HIRA is required for proficient H3.3 deposition and gene activation, demonstrating that the phosphorylation switch is exploited to modulate HIRA/H3.3-mediated muscle gene regulation during myogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
HIRA vs. DAXX: the two axes shaping the histone H3.3 landscape
Experimental and Molecular Medicine
2024 .02
-
Histone tail cleavage as a novel epigenetic regulatory mechanism for gene expression
BMB Reports
2018 .01
-
The Essential Function of miR-5739 in Embryonic Muscle Development
한국생물공학회 학술대회
2021 .04
-
microRNA for determining the age-related myogenic capabilities of skeletal muscle
BMB Reports
2015 .01
-
The role of PDIA3 in myogenesis during muscle regeneration
Experimental and Molecular Medicine
2020 .01
-
Regulation of cellular gene expression by nanomaterials
Nano Convergence
2018 .11
-
MiR-183-5p induced by saturated fatty acids regulates the myogenic differentiation by directly targeting FHL1 in C2C12 myoblasts
BMB Reports
2020 .01
-
Identification of small molecules that inhibit the histone chaperone Asf1 and its chromatin function
BMB Reports
2015 .01
-
A short guide to histone deacetylases including recent progress on class II enzymes
Experimental and Molecular Medicine
2020 .02
-
miR-3074-3p promotes myoblast differentiation by targeting Cav1
BMB Reports
2020 .01
-
Inducing Myogenic Differentiation of Human Mesenchymal Stem Cells through the 3D Co-culture with Myoblasts on Double-sided Scaffold
한국고분자학회 학술대회 연구논문 초록집
2017 .04
-
골격근 손상 및 재생 환경에서의 근육 세포 군집 이동의 물리적 특성 가시화
한국가시화정보학회지
2022 .07
-
상지 근육 내 운동 세트별 근피로도 유발 정도 비교
대한전자공학회 학술대회
2023 .06
-
Osteogenic differentiation of stem cells by endogenous gene activation with blue light
한국생물공학회 학술대회
2016 .10
-
Epigenetic role of nuclear S6K1 in early adipogenesis
BMB Reports
2016 .01
-
Epigenetic regulation and chromatin remodeling in learning and memory
Experimental and Molecular Medicine
2017 .01
-
충격 시 근활성도에 따른 머리/목 거동 변화 분석 : 상세 목 근육 유한요소 모델을 이용한 연구
한국정밀공학회 학술발표대회 논문집
2015 .05
-
Design of Polymeric Gene Carriers for Highly Efficient Gene Expression through Regulation of Cellular Uptake
한국고분자학회 학술대회 연구논문 초록집
2016 .10
-
Future Muscle Food : Status and Prospects of Cultured Meat
한국생물공학회 학술대회
2021 .04
-
Combining a micro/nano-hierarchical scaffold with selective plasma treatment to induce cell alignment and differentiation for muscle tissue regeneration
대한기계학회 춘추학술대회
2016 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0