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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 357 - 366 (10page)
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초록· 키워드
오류제보하기
Quorum sensing (QS) is involved in the process of cell-to-cell communication and as a gene regulatory mechanism, which has been implicated in bacterial pathogenicity. Bacteria use this QS system to control a variety of physiological processes. In this study, pomegranate (Punica granatum L.) peel extract (PPE) was first screened for its ability to inhibit QS in bio-reporter strains (Chromobacterium violaceum and C. violaceum CV026). Next, the ability of PPE to inhibit swimming motility and biofilm formation was examined in Y. enterocolitica. Additionally, changes in the expression of specific genes involved in the synthesis of the N-acylhomoserine lactones (AHLs; yenI and yenR) and in the flagellar regulon (fliA, fleB and flhDC) were evaluated by reverse transcription (RT)-PCR. The results show that PPE specifically inhibited and reduced QS-controlled violacein production by 78.5% in C. violaceum CV026, and decreased QS-associated biofilm formation and swimming motility in Y. enterocolitica without significantly affecting bacterial growth. These inhibitory effects were also associated with the downregulation of gene expression involved in the synthesis of AHLs and in motility. Our results suggest that PPE could be a potential therapeutic agent to prevent enteropathogens in humans, as well as highlight the need to further investigate the in vivo properties of PPE for clinical applications.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Adonizio AL / 2006 / Antiquorum sensing activity of medicinal plants in southern Florida / J. Ethnophamacol 105 : 427 ~ 435
Al-Zoreky NS / 2009 / Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels / Int. J. Food Microbiol 134 : 244 ~ 248
Atkinson S / 2006 / Quorum sensing in Yersinia enterocolitica controls swimming and swarming motility / J. Bacteriol 188 : 1451 ~ 1461
Atkinson S / 2008 / Functional interplay between the Yersinia Pseudotuberculosis YpsRI and YtbRI quorum sensing systems modulates swimming motility by controlling expression
Brackman G / 2009 / Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia / Res. Micro
Al-Zoreky NS / 2009 / Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels / Int. J. Food Microbiol 134 : 244 ~ 248
Atkinson S / 2006 / Quorum sensing in Yersinia enterocolitica controls swimming and swarming motility / J. Bacteriol 188 : 1451 ~ 1461
Atkinson S / 2008 / Functional interplay between the Yersinia Pseudotuberculosis YpsRI and YtbRI quorum sensing systems modulates swimming motility by controlling expression
Brackman G / 2009 / Use of quorum sensing inhibitors to interfere with biofilm formation and development in Burkholderia multivorans and Burkholderia cenocepacia / Res. Micro
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